Study of inflammation control mechanism by IL-27 receptor signaling

2008 Fiscal Year Final Research Report

• Project/Area Number: 19790363
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Saga University
• Principal Investigator: MIYAZAKI Yoshiyuki Saga University, 医学部, 助教 (40380779)
• Project Period (FY): 2007 – 2008
• Keywords: サイトカイン / サイトカイン受容体

Research Abstract

本研究では、遺伝子欠損マウスを用いて、アレルギー性疾患におけるIL-27受容体シグナルの役割を検討し、特に、遅延型過敏反応などで、IFN-gやIL-17を始めとする炎症性サイトカイン産生の抑制に働き、病態を軽減させることを明らかにした。トリパノソーマ感染時の炎症では、残念ながらIL-27のIL-17産生に対する抑制作用を確認することが出来なかったが、IL-17自体は、感染防御免疫の増強に重要な役割を果たすことを明らかにした。

Research Products

• [Journal Article] Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signaling (2009)
  • Author(s): Shimanoe Y, Miyazaki Y, Hara H, Inokuchi A, Yoshida H
  • Journal Title: Ann Allergy Asthma Immunol 102(3) Pages: 223-232
• [Journal Article] Interleukin 27 signaling pathways in regulation of immune and autoimmune responses (2008)
  • Author(s): Yoshida H, Miyazaki Y
  • Journal Title: Int. J. Biochem. Cell Biol 40(11) Pages: 2379-2383
• [Journal Article] Regulation of immune responses by interleukin-27 (2008)
  • Author(s): Yoshida H, Miyazaki Y
  • Journal Title: Immunol Rev 226 Pages: 234-247
• [Journal Article] Amelioration of delayed-type hypersensitivity responses by IL-27 administration (2008)
  • Author(s): Miyazaki Y, Shimanoe Y, Wang S, Yoshida H
  • Journal Title: Biochem Biophys Res Commun 373(3) Pages: 397-402
• [Journal Article] Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis (2008)
  • Author(s): Yoshimura T, Sonoda KH, Miyazaki Y, Iwakura Y, Ishibashi T, Yoshimura A, Yoshida H
  • Journal Title: Int. Immunol 20(2) Pages: 209-214
• [Journal Article] Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1(IL-27R) deficiency (2007)
  • Author(s): Wang S, Miyazaki Y, Shinozaki Y, Yoshida H
  • Journal Title: J. Immunol 179(10) Pages: 6421-6428
• [Journal Article] Regulation of Defense Responses against Protozoan Infection by Interleukin-27 and Related Cytokines (2007)
  • Author(s): Yoshida H, Miyazaki Y, Wang S, Hamano S
  • Journal Title: J. Biomed. Biotechnol 2007(3) Pages: 79401(1-7)
• [Presentation] Role of CARD9 in anti-protozoan defense (2008)
  • Author(s): 島ノ江洋平,宮崎義之,原博満,吉田裕樹
  • Organizer: 第38回日本免疫学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20081201-03
• [Presentation] Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity (2008)
  • Author(s): Shinozaki Y, Miyazaki Y, Hara H, Yoshida H
  • Organizer: 第38回日本免疫学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20081201-03
• [Presentation] Therapeutic potential of IL-27 for inflammatory and autoimmune diseases (2008)
  • Author(s): Miyazaki Y, Nakashima H, Yoshida H
  • Organizer: 7th joint conference of the international cytokine society and the international society for interferon and cytokine research
  • Place of Presentation: Montreal, Canada
  • Year and Date: 20081012-16
• [Presentation] Interleukin-27およびその受容体による遅延型過敏反応の抑制 (2008)
  • Author(s): 宮崎義之,島ノ江洋平,王森,吉田裕
  • Organizer: 第73回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 20080710-12
• [Presentation] Interleukin-17 is necessary for host's protection against acute phase Trypanosoma cruzi infection (2007)
  • Author(s): Miyazaki Y, Shimanoe Y, Wang S, Hamano S, Iwakura Y, Yoshida H
  • Organizer: 第37回日本免疫学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] The role of IL-27(IL-27R) in experimental allergic rhinitis (2007)
  • Author(s): Shimanoe Y, Wang S, Miyazaki Y, Hara H, Yoshida H
  • Organizer: 第37回日本免疫学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Interleukin-17 is required for protection against Trypanosoma cruzi through induction of inflammatory responses (2007)
  • Author(s): Yoshida H, Wang S, Shimanoe Y, Iwakura Y, Miyazaki Y
  • Organizer: Cytokines in Health and Disease ; 15th Annual meeting of the International cytokine society(ICS)
  • Place of Presentation: CA, USA
  • Year and Date: 2007-10-27
• [Presentation] Interleukin-17 is necessary for host protection against acute phase Trypanosoma cruzi infection (2007)
  • Author(s): Yoshida H, Shimanoe Y, Wang S, Hamano S, Iwakura Y, Miyazaki
  • Organizer: The 7th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 兵庫
  • Year and Date: 2007-09-01
• [Presentation] The role of IL-27(IL-27R) in experimental allergic rhinitis. ICMI 2007 (2007)
  • Author(s): Shimanoe Y, Wang S, Miyazaki Y, Hara H, Yoshida H
  • Organizer: 13th internatioal congress of mucosal immunology
  • Place of Presentation: 東京
  • Year and Date: 2007-07-10
• [Presentation] IL-27によるTh17分化制御と、免疫・炎症抑制機構の解析 (2007)
  • Author(s): 吉田裕樹,宮崎義之,王森
  • Organizer: 第72回日本インターフェロン・サイトカイン学会(JSICR)学術集会
  • Place of Presentation: 京都
  • Year and Date: 2007-07-05
• [Presentation] クルーズトリパノソーマに対する感染防御におけるInterleukin-17の役割 (2007)
  • Author(s): 宮崎義之,島ノ江洋平,王森,岩倉洋一郎,吉田裕樹
  • Organizer: 第72回日本インターフェロン・サイトカイン学会(JSICR)学術集会
  • Place of Presentation: 京都
  • Year and Date: 2007-07-05
• [Presentation] Interleukin-17 plays a role in successful resolution of Trypanosoma cruzi infection (2007)
  • Author(s): Yoshida H, Wang S, Iwakura Y, Miyazaki Y
  • Organizer: Immunology 2007 ; 94th annual meeting of the american association of immunologists(AAI)
  • Place of Presentation: FL, USA
  • Year and Date: 2007-05-19