2008 Fiscal Year Final Research Report
Immune regulation of B cells and platelets by mast cells on Helicobacter pylori infection
| Project/Area Number |
19790364
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
NAGAI Shigenori Keio University, 医学部, 助教 (50348801)
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Keywords | 細胞 / 感染免疫 |
|---|
| Research Abstract |
ヘリコバクターピロリ(Helicobacter pylori ; H. pylori)を、肥満細胞欠損マウスに感染させると、コントロール群に比べ抗体産生細胞である形質細胞が胃粘膜固有層に多く浸潤し、血清中に抗原特異的Ig産生が多く検出された。また、肥満細胞欠損により脾臓内巨核球の数が増加していることが確認された。すなわちH. pylori感染時に、肥満細胞が全身性に免疫系を制御することが示された。
|
Research Products
(14 results)
-
-
-
[Journal Article] Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation.2009
Author(s)
Suzuki M, Mimuro H, Kiga K, Fukumatsu M, Ishijima N, Morikawa H, Nagai S, Koyasu S, Gilman RH, Kersulyte D, Berg DE, Sasakawa C.
-
Journal Title
Cell Host Microbe 5(1)
Pages: 23-34
Peer Reviewed
-
[Journal Article] The role of DC-STAMP in maintenance of immune tolerance through regulation of dendrtic cell function.2008
Author(s)
Sawatani Y, Miyamoto T, Nagai S, Maruya M, Imai J, Fujita N, Miyamoto K, Ninomiya K, Suzuki T, Iwasaki R, Toyama Y, Koyasu S, Suda T.
-
Journal Title
Int. Immunol 20(10)
Pages: 1259-1268
Peer Reviewed
-
-
-
[Journal Article] Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach.2007
Author(s)
Mimuro H, Suzuki T, Nagai S, Rieder G, Suzuki M, Nagai T, Fujita Y, Nagamatsu K, Ishijima N, Koyasu S, Haas R, Sasakawa C.
-
Journal Title
Cell Host Microbe. 2(4)
Pages: 250-263
Peer Reviewed
-
-
-
-
-
-
-
