2010 Fiscal Year Final Research Report
The effect of inhaled Di (2-ethylhexyl) phthalate exposued to prepubertal or pregnant female rats for the reproductive function and pharmacokinetics.
| Project/Area Number |
19790408
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
KONDO Tomoko Health Sciences University of Hokkaido, 薬学部, 講師 (70374254)
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| Project Period (FY) |
2007 – 2010
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| Keywords | フタル酸 / DEHP / 吸入曝露 / 生殖 / 毒性 |
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| Research Abstract |
I evaluated the effects of inhaled Di(2-ethylhexyl)phthalate(DEHP) on the reproductive of immature female rats and next-generation effects. It was cleared that DEHP exposure via inhalation for immature female rats may advance puberty onset and alter postpubertal reproductive functions. In the study of DEHP inhalation for pregnant rats, fetal body weight was decreased and fetal testicular testosterone concentration and the expression of mRNA were also decreased.
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Research Products
(2 results)
