Roles of Event-Related Synchronization and Functional Connectivity in Brain Processing and Central Modulation of Gastrointestinal Perception

2008 Fiscal Year Final Research Report

• Project/Area Number: 19790454
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: WATANABE Satoshi Tohoku University, 大学院・医学系研究科, 助手 (40431506)
• Project Period (FY): 2007 – 2008
• Keywords: 過敏性腸症侯群 / 内臓知覚 / 機能的神経回路 / 催眠暗示 / オキシトシン / 情動制御 / 脳機能画像 / 大脳誘発電位

Research Abstract

消化管知覚過敏は、過敏性腸症候群の病態生理を一元的に説明しうる主要な病態の一つである。先行研究において、消化管刺激誘発性の脳活動は複数の脳領域における血流量増加を引き起こすことが明らかにされている。本研究では、内臓刺激中に測定した脳波データと脳機能画像データを、時間周波数解析および共分散構造解析技法を駆使して再解析し、消化管知覚中枢処理過程の時空間パターンとその高次相関を抽出することで機能的神経回路を推定、特定することを目的とした。(1)時間周波数解析の結果、消化管知覚特異的な時間周波数成分として、150m秒付近におけるgamma帯域の事象関連同期性とtheta帯域の事象関連同期性が抽出され、いずれも過敏性腸症侯群患者の方で高い同期性パワーを示すことが明らかとなった。(2)共分散構造解析の結果、眼窩前頭皮質が右背外側前頭前野の活性化と腹部症状の変容効果との関連に対して有意な仲介効果を示すことが明らかとなった。以上、平成19〜20年度研究費により、過敏性腸症候群における右前頭部からのトップダウン経路による痛み修飾の機能不全とそれに伴う視床-皮質ニューロンのボトムアップ経路の活性充進という病態生理の存在が示唆された。さらに具体的な脳部位として、右背外側前頭前野と眼窩前頭皮質の機能的結びつきが重要であることが示唆された。

Research Products

• [Journal Article] The Role of Neural Oscillation in the Brain Processing of Visceral Sensory Information. (2008)
  • Author(s): Watanabe S, Hattori T, Kanazawa M, Kano M, Fukudo S.
  • Journal Title: Neuroscience Research 61S Pages: S182
  • Peer Reviewed
• [Journal Article] Cerebral evoked potentials during visceral stimulation in non-consulters with functional dyspepsia. (2008)
  • Author(s): Morishita J, Shoji T, Endo Y, Sagami Y, Watanabe S, Kanazawa M, Kimura Y, Machida T, Machida T, Fukudo S, Hongo M.
  • Journal Title: Gastroenterology 134 Pages: A531
  • Peer Reviewed
• [Journal Article] Effects of mosapride citrate, a 5-HT4 receptor agonist, on rectosigmoid motor and sensory function in patients with irritable bowel syndrome. (2008)
  • Author(s): Kanazawa M, Watanabe S, Tana C, Fukudo S.
  • Journal Title: Gastroenterology 134 Pages: A550-1
  • Peer Reviewed
• [Journal Article] Gamma Oscillation Reflect the Dysfunctional Visceral Sensory Processing and Modulation in Irritable Bowel Syndrome. (2008)
  • Author(s): Watanabe S, Hattori T, Kanazawa M, Kano M, Fukudo S.
  • Journal Title: Gastroenterology 134suppl1 Pages: A557-8
  • Peer Reviewed
• [Journal Article] Changes in brain function by hypnotic suggestion in patients with irritable bowel syndrome and healthy subjects. (2008)
  • Author(s): Fukudo S, Terui T, Watanabe S, Hamaguchi T, Yanai K, Itoh M, Kanazawa M.
  • Journal Title: Psychosomatic Medicine 70 Pages: A100
  • Peer Reviewed
• [Journal Article] Individual differences in work overload predict the response of the rostral anterior cingulate cortex to acute interoceptive stressor. (2008)
  • Author(s): Watanabe S, Kanazawa M, Terui T, Mine H, Hamaguchi T, Yanai K, Itoh M, Fukudo S.
  • Journal Title: Psychosomatic Medicine 70suppl:A60 Pages: A60
  • Peer Reviewed
• [Journal Article] 創造性育成を目指した教育ツール開発と評価に関する研究ブレインストーミング法によるストレス反応軽減効果の検討. (2008)
  • Author(s): 西浦和樹、伊藤利憲、石井力重、田山淳、渡辺諭史.
  • Journal Title: 発達科学研究 8 Pages: 71-80
  • Peer Reviewed
• [Journal Article] 高校生版食行動尺度の作成と肥満度に関連する食行動要因の検討. (2008)
  • Author(s): 田山淳、渡辺諭史、西浦和樹、宗像正徳、福土審.
  • Journal Title: 心身医学 48(3) Pages: 217-227
  • Peer Reviewed
• [Journal Article] 内臓知覚の中枢神経プロセシングにおける神経活動同期性の検証. (2008)
  • Author(s): 渡辺諭史、服部朝美、金澤素、鹿野理子、福土審.
  • Journal Title: 消化管運動 10(1) Pages: 27-29
• [Journal Article] 過敏性腸症候群患者におけるクエン酸モサプリドの直腸運動機能・内臓知覚に対する効果. (2008)
  • Author(s): 金澤素、渡辺諭史、多那千絵、福土審.
  • Journal Title: Therapeutic Research 29(4) Pages: 520-521
• [Journal Article] Role of histaminergic neurons in cognitive control of hypersensitive visceral perception. (2007)
  • Author(s): Watanabe S, Hattori T, Kanazawa M, Kano M, Fukudo S.
  • Journal Title: Neuroscience Research 58S Pages: S219
  • Peer Reviewed
• [Journal Article] Site-specific differences in central motility responses processing of visceral stimuli from the descending colon and the rectum in humans. (2007)
  • Author(s): Kanazawa M, Hamaguchi T, Watanabe S, Terui T, Mine H, Kano M, Itoh M, Fukudo S.
  • Journal Title: Gastroenterology 132(4)suppl2 Pages: A600
  • Peer Reviewed
• [Journal Article] Differential Modulation of the Regional Brain by Hypnotic Suggestion between Patients with Irritable Bowel Syndrome and Healthy Subjects. (2007)
  • Author(s): Terui T, Watanabe S, Kanazawa M, Mine H, Hamaguchi T, Yanai K, Itoh M, Fukudo S.
  • Journal Title: Gastroenterology 132(4)supol2 Pages: A134
  • Peer Reviewed
• [Journal Article] Hypnotic modulation of regional brain activity to rectal stimulation using Positron emission tomography. (2007)
  • Author(s): Watanabe S, Kanazawa M, Lane RD, Terui T, Mine H, Hamaguchi T, Yanai K, Itoh M, Fukudo S.
  • Journal Title: Gastroenterology 132(4)suppl2 Pages: A726
  • Peer Reviewed
• [Journal Article] 消化管知覚の催眠変容における脳領域間functional connectivityの検証. (2007)
  • Author(s): 渡辺諭史、金澤素、濱口豊太、照井隆広、三根浩敬、谷内一彦、伊藤正敏、福土審.
  • Journal Title: 消化管運動 9(1) Pages: 29-30
• [Journal Article] 内臓知覚と中枢神経プロセシング(解説). (2007)
  • Author(s): 渡辺諭史、金澤素、福土審.
  • Journal Title: 治療学 14(6) Pages: 26-28
• [Journal Article] 労働ストレス要因と脳内ストレス処理過程への影響(総説) (2007)
  • Author(s): 渡辺諭史、金澤素、福土審.
  • Journal Title: 心療内科学 11(6) Pages: 6-11
  • Peer Reviewed
• [Journal Article] 過敏性腸症候群における心理療法と脳機能イメージング(総説). (2007)
  • Author(s): 渡辺諭史、金澤素、福土審.
  • Journal Title: 消化器心身医学 14(1) Pages: 6-11
  • Peer Reviewed
• [Journal Article] Role of Histaminergic Neurons in Hypnotic Modulation of Brain Processing of Visceral Perception. (2007)
  • Author(s): Watanabe S, Hattori T, Kanazawa M, Kano M, Fukudo S.
  • Journal Title: Neurogastroenterology and Motility 19 Pages: 831-838
  • Peer Reviewed
• [Journal Article] Brain activation correlated with changes in heart rate and autonomic functions during rectal distention.
  • Author(s): Suzuki H, Watanabe S, Hamaguchi T, Kanazawa M, Ohisa N, Maruyama M, Yanbe T, Fukudo S.
  • Journal Title: Psychosomatic Medicine (in press)
  • Peer Reviewed
• [Presentation] The Role of Neural Oscillation in the Brain Processing of Visceral Sensory Information. (2008)
  • Author(s): 渡辺諭史,服部朝美、金澤素、鹿野理子、福士審.
  • Organizer: 第31回日本神経科学学会
  • Place of Presentation: 東京
  • Year and Date: 20080709-11
• [Presentation] Cerebral evoked potentials during visceral stimulation in non-consulters with functional dyspepsia. (2008)
  • Author(s): Morishita J, Shoji T, Endo Y, Sagami Y, Watanabe S, Kanazawa M, Kimura Y, Machida T, Machida T, Fukudo S, Hongo M.
  • Organizer: The 109th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: SanDiego, USA
  • Year and Date: 20080517-22
• [Presentation] Effects of mosapride citrate, a 5-HT4 receptor agonist, on rectosigmoid motor and sensory function in patients with irritable bowel syndrome. (2008)
  • Author(s): Kanazawa M, Watanabe S, Tana C, Fukudo S.
  • Organizer: The 109th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: SanDiego, USA
  • Year and Date: 20080517-22
• [Presentation] Gamma Oscillation Reflect the Dysfunctional Visceral Sensory Processing and Modulation in Irritable Bowel Syndrome. (2008)
  • Author(s): Watanabe S, Hattori T, Kanazawa M, Kano M, Fukudo S.
  • Organizer: The 109th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: SanDiego, USA
  • Year and Date: 20080517-22
• [Presentation] Individual differences in work overload predict the response of the rostral anterior cingulate cortex to acute interoceptive stressor. (2008)
  • Author(s): Watanabe S, Kanazawa M, Terui T, Mine H, Hamaguchi T, Yanai K, Itoh M, Fukudo S.
  • Organizer: The 66th Annual Meeting of American Psychosomatic Society
  • Place of Presentation: Baltimore, USA
  • Year and Date: 20080313-15
• [Presentation] Changes in brain function by hypnotic suggestion in patients with irritable bowel syndrome and healthy subjects. (2008)
  • Author(s): Fukudo S, Terui T, Watanabe S, Hamaguchi T, Yanai K, Itoh M, Kanazawa M.
  • Organizer: The 66th Annual Meeting of American Psychosomatic Society
  • Place of Presentation: Baltimore, USA
  • Year and Date: 20080313-15
• [Presentation] 過敏性腸症候群における内臓知覚の脳機能画像-催眠変容に抵抗する神経回路の証明-. (2008)
  • Author(s): 渡辺諭史,照井隆広、金澤素、濱口豊太、相模泰宏、庄司知隆、遠藤由香、本郷道夫、伊藤正敏、福土審.
  • Organizer: 第8回IBS Forum
  • Place of Presentation: 東京
  • Year and Date: 2008-11-22
• [Presentation] 過敏な内臓知覚の認知的修飾過程におけるヒスタミンニューロンの役割. (2007)
  • Author(s): 渡辺諭史、服部朝美、金澤素、鹿野理子、福土審.
  • Organizer: 第30回日本神経科学学会(Neuro2007)
  • Place of Presentation: 横浜
  • Year and Date: 20070911-13
• [Presentation] Hypnotic modulation of regional brain activity to rectal stimulation using Positron emission tomography. (2007)
  • Author(s): Watanabe S, Kanazawa M, Lane RD, Terui T, Mine H, Hamaguchi T, Yanai K, Itoh M, Fukudo S.
  • Organizer: The 108th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20070519-24
• [Presentation] Differential Modulation of the Regional Brain by Hypnotic Suggestion between Patients with Irritable Bowel Syndrome and Healthy Subjects. (2007)
  • Author(s): Terui T, Watanabe S, Kanazawa M, Mine H, Hamaguchi T, Yanai K, Itoh M, Fukudo S.
  • Organizer: The 108th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20070519-24
• [Presentation] Site-specific differences in central motility responses processing of visceral stimuli from the descending colon and the rectum in humans. (2007)
  • Author(s): Kanazawa M, Hamaguchi T, Watanabe S, Terui T, Mine H, Kano M, Itoh M, Fukudo S.
  • Organizer: The 108th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20070519-24
• [Presentation] 内臓感覚の中枢神経プロセシングにおける神経活動同期性の検証. (2007)
  • Author(s): 渡辺諭史,服部朝美、金澤素、鹿野理子、福土審.
  • Organizer: 第6回日本神経消化器病学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-03
• [Book] 「催眠」川上憲人他編:ストレス科学辞典
  • Author(s): 渡辺諭史.
  • Publisher: パブリックヘルスリサーチセンター(in press)
• [Book] 「暗示効果」川上憲人他編:ストレス科学辞典
  • Author(s): 渡辺諭史.
  • Publisher: パブリックヘルスリサーチセンター(in press)
• [Remarks] 東北大学研究者紹介データベース
  • URL: http://db.tohoku.ac.jp/whois/detail/050ced79380ee7c2cfbd8b3e622bc792.html