2008 Fiscal Year Final Research Report
Esophageal mucosal defense mechanisms and a new pathophysiological classification by intercellular junctional complex
| Project/Area Number |
19790501
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
OSHIMA Tadayuki Hyogo College of Medicine, 医学部, 講師 (00381814)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 逆流性食道炎 / タイト結合 / クローディン |
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| Research Abstract |
食道粘膜防御機構を解析する上で,種々の実験的操作を行うには不可欠である食道粘膜上皮様重層扁平上皮初代培養細胞系を世界で初めて確立した.また粘膜透過性上昇には,酸以外に胆汁酸が重要な役割をしていることを見出した.
一方ヒト食道生検組織では,非びらん性食道炎患者の食道粘膜上皮基底層の細胞間間隙の開大が認められ,この開大とタイト結合蛋白の発現との相関を明らかとすべく継続して解析を進めている.
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Research Products
(17 results)
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[Journal Article] Interobserver agreement in endoscopic evaluation of reflux esophagitis using a modified Los Angeles classification incorporating grades N and M: a validation study in a cohort of Japanese endoscopists2008
Author(s)
Miwa H, Yokoyama T, Hori K, Sakagami T, Oshima T, Tomita T, Fujiwara Y, Saita H, Itou T, Ogawa H, Nakamura Y, Kishi K, Murayama Y, Hayashi E, Kobayashi K, Tano N, Matsushita K, Kawamoto H, Sawada Y, Ohkawa A, Arai E, Nagao K, Hamamoto N, Sugiyasu Y, Sugimoto K, Hara H, Tanimura M, Honda Y, Isozaki K, Noda S, Kubota S, Himeno S
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Journal Title
Dis Esophagus 21
Pages: 355-63
Peer Reviewed
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