Molecular genetics of atrial fibrillation and evaluation of upstream therapy for atrial fibrillation

2009 Fiscal Year Final Research Report

• Project/Area Number: 19790520
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: HAYASHI Kenshi Kanazawa University, 附属病院, 助教 (00422642)
• Project Period (FY): 2007 – 2009
• Keywords: 心臓病態学

Research Abstract

Atrial fibrillation (AF) has an enormous social impact because of its very high incidence, its potential for devastating clinical consequences, and the difficulty of its management . Hypertrophic cardiomyopathy (HCM) is well known risk factor for AF. However, significant proportions of patients, up to 30% in some large studies, develop AF in the absence of risk factors. We performed genetic analysis for 75 patients with lone or familial AF, and identified 3 mutations. We also clarified that the HCM patients with angiotensinogen 1 A/C polymorphism, TNNT2 mutation, or TNNI3 mutation easily develop AF compared to those without these polymorphism or mutations.

Research Products

• [Journal Article] Impact of QT variables on clinical outcome of genotyped hypertrophic cardiomyopathy. (2009)
  • Author(s): Uchiyama K, Hayashi K, Fujino N, Sakamoto Y, Yamagishi M., 他5名2番目
  • Journal Title: Ann Noninvasive Electrocardiol 14 Pages: 65-71
  • Peer Reviewed
• [Journal Article] Long QT syndrome and associated gene mutation carriers in Japanese children: results from ECG screening examinations. (2009)
  • Author(s): Hayashi K, Fujino N, Uchiyama K, Ino H, Sakata K, Konno T, Masuta E, Funada A, Sakamoto Y, Tsubokawa T, Nakashima K, Liu L, Higashida H, Hiramaru Y, Shimizu M, Yamagishi M.
  • Journal Title: Clin Sci (Lond). 117(12) Pages: 415-24
  • Peer Reviewed
• [Journal Article] Assessment of QT intervals and prevalence of short QT syndrome in Japan. (2008)
  • Author(s): Funada A, Hayashi K, Ino H, Fujino N, Uchiyama K, Sakata K, Masuta E, Sakamoto Y, Tsubokawa T, Yamagishi M.
  • Journal Title: Clin Cardiol. 31(6) Pages: 270-4
  • Peer Reviewed
• [Journal Article] Trafficking-Competent KCNQ1 Variably Influences the Function of HERG Long QT Alleles.
  • Author(s): Hayashi K, Shuai W, Sakamoto Y, Higashida H, Yamagishi M, Kupershmidt S.
  • Journal Title: Heart Rhythm. (in press)
  • Peer Reviewed
• [Presentation] パネルディスカッション7「心房細動の治療戦略」PD-7-3「肥大型心筋症における心房細動発症と対策:原因遺伝子が同定された症例群での検討」 (2009)
  • Author(s): 舟田晃, 藤野陽, 林研至, 井野秀 一, 山岸正和
  • Organizer: 第57回日本心臓病学会学術集会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2009-09-19
• [Presentation] Impact of renin-angiotensin system polymorphisms on occurrence of atrial fibrillation associated with heart failure in hypertrophic cardiomypathy: results from clinical and gene analyses of genotyped patients. (2009)
  • Author(s): Funada A, Ino H, Fujino N, Hayashi K, Uchiyama K, Masuta E, Sakamoto Y, Tsubokawa T, Muramoto A, Yamagishi M
  • Organizer: American College of Cardiology 58th annual scientific session
  • Place of Presentation: Orange county convention center (USA)
  • Year and Date: 2009-03-29
• [Presentation] Impact of troponin-gene mutations on occurrence of atrial fibrillation and development of left atrial dilatation in hypertrophic cardiomyopathy (2009)
  • Author(s): Funada A, Ino H, Fujino N, Hayashi K, Uchiyama K, Masuta E, Sakamoto Y, Tsubokawa T, Muramoto A, Yamagishi M
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2009-03-28
• [Presentation] Impact of angiotensin II Type 1 receptor A/C1166 gene polymorphism on the onset of atrial fibrillation in genotyped hypertrophic cardiomyopathy (2008)
  • Author(s): Funada A, Ino H, Fujino N, Hayashi K, Uchiyama K, Sakata K, Masuta E, Fujita T, Sakamoto Y, Tsubokawa T, Yamagishi M.
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2008-03-28
• [Presentation] Association between atrial fibrillation and left atrial diameter in genotyped populations of hypertrophic cardiomyopathy: results from a longitudinal study (2008)
  • Author(s): Funada A, Ino H, Fujino N, Hayashi K, Uchiyama K, Sakata K, Masuta E, Fujita T, Sakamoto Y, Tsubokawa T, Yamagishi M.
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2008-03-28