2008 Fiscal Year Final Research Report
Examination for the contribution of the angiotensin II type1 receptor to the development of malignant arrhythmias in hypertrophied and failing hearts
| Project/Area Number |
19790525
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
中西 道郎 Kyoto University, 医学研究科, 非常勤講師 (60378726)
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| Project Period (FY) |
2007 – 2008
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| Keywords | アンジオテンシン / 不整脈 / 心肥大 |
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| Research Abstract |
アンジオテンシンIIタイプ1a(AT1a)受容体欠損マウス(AT1aK0)を用いてレニン・アンジオテンシン系の頻拍性不整脈発生への関与とその分子機序を検討した。AT1a欠損は肥大心において悪性不整脈の発生を減少させ、また心不全・突然死モデルマウスの生存率を改善し、その機序としてgap junctionを形成するconnexin43蛋白発現低下抑制が考えられた。以上よりレニン・アンジオテンシン系阻害薬の抗不整脈効果とその機序が明らとなった。
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Research Products
(5 results)
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[Journal Article] Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death2009
Author(s)
Yasuno S, Usami S, Kuwahara K, Nakanishi M, Arai Y, Kinoshita H, Nakagawa Y, Fujiwara M, Murakami M, Ueshima K, Harada M, Nakao K.
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Journal Title
Am J Physiol Heart Circ Physiol (in press)
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[Journal Article] Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation2007
Author(s)
Nakanishi M, Harada M, Kishimoto I, Kuwahara K, Kawakami R, Nakagawa Y, Yasuno S, Usami S, Kinoshita H, Adachi Y, Fukamizu A, Saito Y, Nakao K.
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Journal Title
Circ J. 71(8)
Pages: 1310-6
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[Presentation] Functional inhibition of p300 in the post-natal heart leads tomitochondrial dysfunction and cell death in mice2008
Author(s)
Nakagawa Y, Kuwahara K, Akao M, Katoh M, Takemura G, Takano M, Harada M, Murakami M, Nakanisi M, Usami S,Yasuno S, Kinoshita H, Fuziwara M, Kuwabara Y, Kenj Ueshima K, Nakao K.
Organizer
The 72nd Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
福岡
Year and Date
20080328-30
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