Development of the new cardiovascular disease therapy making the most of unique characterization of physiologically active peptides.

2008 Fiscal Year Final Research Report

• Project/Area Number: 19790548
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: TOKUDOME Takeshi National Cardiovascular Center Research Institute, 高血圧研究室, 室長 (00443474)
• Project Period (FY): 2007 – 2008
• Keywords: 心臓病態学

Research Abstract

心筋梗塞モデル動物を用いた検討により、胃から分泌される摂食亢進ホルモンであるグレリンの投与が、心筋梗塞急性期の致死性不整脈の発生を、交感神経活動抑制により顕著に減少させ、死亡率を有意に減少させることに成功した。

Research Products

• [Journal Article] Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats. (2008)
  • Author(s): Schwenke DO, Tokudome T, Shirai M, Hosoda H, Horio T, Kishimoto I, Kangawa K
  • Journal Title: Endocrinology 149(1) Pages: 237-44
• [Journal Article] Ghrelin Suppresses Cardiac Sympathetic Activity and Prevents Early Left Ventricular Remodeling in Rats With Myocardial Infarction. (2008)
  • Author(s): Soeki T, Kishimoto I, Schwenke DO, Tokudome T, Horio T, Yoshida M, Hosoda H, Kangawa K
  • Journal Title: Am J Physiol Heart Circ Physiol 294(1) Pages: H426-32
• [Journal Article] RGS4 mediates anti-hypertrophic effect of locally secreted natriuretic peptides in the heart. (2008)
  • Author(s): Tokudome T, Kishimoto I, Horio T, Arai Y, Schwenke DO, Hino J, Okano I, Kawano Y, Kohno M, Miyazato M, Nakao K,Kangawa K
  • Journal Title: Circulation 117 Pages: 2329-2339
• [Journal Article] Early ghrelin treatment following myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. (2008)
  • Author(s): Schwenke DO, Tokudome T, Shirai M, Horio T, Kishimoto I, Klagg P, Kangawa K
  • Journal Title: Endocrinology 149 Pages: 5127-5176
• [Journal Article] Cardioprotective effects of natriuretic peptides. (2007)
  • Author(s): Tokudome T, Kishimoto I, Horio T, kangawa K.
  • Journal Title: Nippon Rinsho 65(Suppl 4) Pages: 165-169
• [Journal Article] C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurons.
  • Author(s): Kishimoto I, Tokudome T, Horio T, Soeki T, Chusho H, Nakao K, Kangawa K
  • Journal Title: J Neuroendocrinol 20(11) Pages: 1213-1223
• [Presentation] Regulator of G-protein Signaling 4 Mediates Antihypertropnic Effect of Endogenous Natriuretic Peptides in the heart.
  • Author(s): 徳留 健
  • Organizer: 第11回日本心不全学会(YIA口演)
• [Remarks]
  • URL: http://www.ncvc.go.jp/res/byoin/byoinj_04.html^#c