2008 Fiscal Year Final Research Report
The role of Dendritic cells for the autoimmune kidney injury
| Project/Area Number |
19790578
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
IWATA Yasunori Kanazawa University, 保健管理センター, 助教 (90432137)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 自己免疫性疾患 / 樹状細胞 |
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| Research Abstract |
ヒト全身性エリテマトーシス類似の病態を呈するMRL-Fas^<lpr>マウスを用いて自己免疫性腎障害における樹状細胞(DCs)とp38MAPKの関与を検討した. われわれの結果よりDCsはp38MAPK活性化を介して自己免疫性臓器障害の進展に関与することが示唆された. 樹状細胞の制御は自己免疫性臓器障害の新たな治療標的として有用であると考えられた。
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[Journal Article] Dendritic cells contribute to autoimmune kidney injury in MRL-Faslpr mice. Dendritic cells contribute to autoimmune kidney injury in MRL-Fas^<lpr> mice.2009
Author(s)
Iwata Y, Furuichi K, Sakai N, Yamauchi H, Shinozaki Y, Shu K, Kurokawa Y, Toyama T, Kitajima S, Okumura T, Yamada S, Maruyama I, Matsushima K, Kaneko S, Wada T
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Journal Title
Journal of Rheumatology. 36
Pages: 306-314
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[Journal Article] Combined pure red cell aplasia and autoimmune hemolytic anemia in systemic lupus erythematosus with anti-erythropoietin autoantibodies.2008
Author(s)
Hara A, Wada T, Kitajima S, Toyama T, Okumura T, Kitagawa K, Iwata Y, Sakai N, Furuichi K, Higuchi M, Kaneko S
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Journal Title
American Journal of hematology 83
Pages: 750-752
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