2010 Fiscal Year Final Research Report
A study of clinical utilization of glycoproteins as a early diagnostic marker of Alzheimer's disease.
| Project/Area Number |
19790605
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Tottori University |
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Principal Investigator |
TANIGUCHI Miyako Tottori University, 医学部, 助教 (50335527)
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| Research Collaborator |
URAKAMI Katsuya 鳥取大学, 医学部, 教授 (30213507)
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| Project Period (FY) |
2007 – 2010
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| Keywords | アルツハイマー病 / 診断マーカー / トランスフェリン / 糖タンパク / 糖鎖 / レクチン |
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| Research Abstract |
We previously discovered that the glycosylation of three glycoproteins were altered in Alzheimer's disease (AD). In this study, we identified all glycoproteins, established the methods to quantify the sugars of each glycoproteins and measured glycosylation of them. Identified serum transferrin and immune system associated protein had altered quantities of several kinds of sugar in AD patients compared with non-demented control (NDC) groups. Sialic acid in Alzheimer's serum transferrin also changed in early stage of AD, which suggests the sialic acid of transferrin is an available serum diagnostic marker of AD. Immune system associated protein had altered sugars compared with not only NDC groups but also non-AD dementia groups, and correlated with cerebrospinal fluid amyloid β(Aβ). This glycoprotein is expected to be an efficient serum marker which can monitor the changes of Aβ in the brain.
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[Journal Article] Alcadein cleavages by amyloid beta-precursor protein (APP) alpha-and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.2009
Author(s)
Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M., Urakami K, ほか(全19人中10番目)
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Journal Title
J Biol Chem 284(52)
Pages: 36024-36033
Peer Reviewed
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[Journal Article] Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease.2008
Author(s)
Taniguchi M, Okayama Y, Hashimoto Y, Kitaura M, Jimbo D, Wakutani Y, Wada-Isoe K, Nakashima K, Akatsu H, Furukawa K, Arai H, Urakami K
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Journal Title
Dement Geriatr Cogn Disord. 26(2)
Pages: 117-122
Peer Reviewed
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