2009 Fiscal Year Final Research Report
The impact of hyperinsulinemia and tuberin in the development of hepatocellular carcinoma
| Project/Area Number |
19790643
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Kurume University |
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Principal Investigator |
KAWAGUCHI Takumi Kurume University, 医学部, 講師 (00320177)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 糖尿病学 |
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| Research Abstract |
Hyperinsulinemia is frequently seen in patients with hepatocellularcarcinoma (HCC). Since insulin is a growth-promoting hormone, hyperinsulinemia may beinvolved in the development of HCC. In this study, we reveled that insulin may associate with the development of HCC though activation of intracellular molecules related to cell proliferation.
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[Journal Article] Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells.2010
Author(s)
Kawaguchi T, Yamagishi S, Itou M, Okuda K, Sumie S, Kuromatsu R, Sakata M, Abe M, Taniguchi E, Koga H, Harada M, Ueno T, Sata M.
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Journal Title
Am J Pathol. 176
Pages: 168-76
Peer Reviewed
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[Journal Article] Supplement improves nutrition and stresses caused by examination-associated fasting in patients with liver cirrhosis.2008
Author(s)
Kawaguchi T, Taniguchi E, Itou M, Mutou M, Ibi R, Shiraishi S, Okada T, Uchida Y, Otsuka M, Tonan T, Fujimoto K, Oriishi T, Tanaka S, Takakura M, Sata M
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Journal Title
Hepatol Res. 38
Pages: 1178-85
Peer Reviewed
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[Journal Article] Body cell mass is a useful parameter for assessing malnutrition and severity of disease in non-ascitic cirrhotic patients with hepatocellular carcinoma or esophageal varices.2008
Author(s)
Kawaguchi T, Taniguchi E, Itou M, Ibi R, Okada T, Mutou M, Shiraishi S, Uchida Y, Otsuka M, Umeki Y, Oriishi T, Hayabuchi H, Tanaka S, Takakura M, Sata M
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Journal Title
Int J Mol Med. 22
Pages: 589-94
Peer Reviewed
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