2009 Fiscal Year Final Research Report
Association of the PD1/PD-L co-stimulatory pathway in lupus nephritis.
| Project/Area Number |
19790701
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | 財団法人田附興風会 (2009)
Tazuke Kofukai Medical Research Institute (2007-2008) |
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Principal Investigator |
HATACHI Saori 財団法人田附興風会, 医学研究所第4研究部, 研究員 (70414117)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 膠原病学 / ループス腎炎 / PD-1 / PD-L1 |
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| Research Abstract |
To investigate the role of the PD-1/PD-L system in the pathology of renal involvement of systemic antoimmune diseases (SAD), we examined the expression of PD-1 and its ligand PD-L1 in renal biopsy specimens from patients with SAD. Immunohistochemical analysis showed that PD-1/PD-L1 was expressed on inflammatory cells infiltrated in the periglomerular regions and on urinary tube epithelial cells. These findings were no relation to the type of SAD and the subclasses of lupus nephritis. Unlikely on our previous report about NZB/W F1 mice, a model of lupus-like nephritis, PD-L1 was not expressed in the glomeruli. These results suggested that the PD-1/PD-L1 pathway may be related to the immunological reaction in the progression to nephritis.
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