2009 Fiscal Year Final Research Report
An artificial placenta using a sheep model
| Project/Area Number |
19790755
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
MIURA Yuichiro Tohoku University, 病院, 特任助手 (20419229)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 人工胎盤 / 人工羊水 / 人工子宮 / 胎児循環 / 膜型人工肺 / 動脈管 / マイクロスフェア法 |
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| Research Abstract |
Our purpose was to develop an artificial placenta in a form of a pumpless arteriovenous extracorporeal life support circuit, in which infant's own blood pressure droved the system. In an animal experiment using the chronically instrumented fetal sheep, we could demonstrate that this system could support gas exchange and maintain fetal circulation for 15~30 hours. Prolonged support assured cerebral oxygen delivery would require a parallel circuit based on a low resistance oxygenator.
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