2009 Fiscal Year Final Research Report
Differentiation-induction therapy with adipocytokine for cutaneous squamous cell carcinoma
| Project/Area Number |
19790791
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Saga University |
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Principal Investigator |
INOUE Takuya Saga University, 医学部, 講師 (50380754)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 皮膚腫瘍学 / 分化誘導療法 |
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| Research Abstract |
We have shown that subcutaneous adipocytes of rats facilitate the differentiation of squamous cell carcinoma cells of the skin in vitro. We hypothesized that adipocyte-derived cytokines have a promoting effect on differentiation of carcinoma cells. We examined the effect of adiponectin on squamous cell carcinoma cells of the skin and investigated the role of adipocytokine on the growth and differentiation of the cancer cells.
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