The effects of sonic hedgehog on lymphangiogenesis in impaired wound healing

2008 Fiscal Year Final Research Report

• Project/Area Number: 19790795
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: ASAI Jun Kyoto Prefectural University of Medicine, 医学研究科, 助教 (50438222)
• Project Period (FY): 2007 – 2008
• Keywords: 皮膚生理学

Research Abstract

ヘッジホッグがマクロファージを介したリンパ管新生を促進することを示した。その機序として、マクロファージ自身のリンパ管内皮細胞への分化を誘導することが明らかになった。ソニックヘッジホッグがリンパ管新生を介した難治性皮膚潰瘍の新しい治療法として有効な治療法となる可能性が示唆された。

Research Products

• [Journal Article] Symmetrical drug-related intertriginous and flexural exanthema caused by valacyclovir. (2009)
  • Author(s): Daito J, Hanada K, Katoh N, Katoh S, Sakamoto K, Asai J, Takenaka H, Kishimoto S.
  • Journal Title: Dermatology 218(1) Pages: 60-2
  • Peer Reviewed
• [Journal Article] Brunsting-Perry cicatricial pemphigoid associated with autoantibodies to the C-terminal domain of BP180. (2008)
  • Author(s): Daito J, Katoh N, Asai J, Ueda E, Takenaka H, Ishii N, Hashimoto T, Kishimoto S.
  • Journal Title: Br J Dermatol 159(4) Pages: 984-6
  • Peer Reviewed
• [Journal Article] Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. (2007)
  • Author(s): Maruyama K, Asai J (co-first author), Ii M, Thorne T, Losordo DW, D'Amore PA.
  • Journal Title: Am J Pathol 170(4) Pages: 1178-91
  • Peer Reviewed
• [Journal Article] Kishimoto S. Infantile myofibromatosis of the scrotum. (2007)
  • Author(s): Ichihashi K, Takenaka H, Asai J, Morihara K, Kimura O, Morishima Y, Katoh N,
  • Journal Title: Eur J Dermatol 18(1) Pages: 82-83
• [Journal Article] 創傷治癒のメカニズム骨髄由来細胞の寄与 (2007)
  • Author(s): 竹中秀也、浅井純、岸本三郎
  • Journal Title: 京津府立医大雑誌 116(9) Pages: 611-618
• [Journal Article] 創傷治癒と局所因子 (2007)
  • Author(s): 浅井純、竹中秀也.
  • Journal Title: MB Derma 129 Pages: 18-23
• [Journal Article] 難治性皮膚潰瘍-病態解明とあらたな治療戦略- (2007)
  • Author(s): 岸本三郎、浅井純、竹中秀也
  • Journal Title: .皮膚病診療 29 Pages: 253-259
• [Journal Article] 創傷治癒と局所因子 (2007)
  • Author(s): 浅井純、竹中秀也
  • Journal Title: MB Derma 129 Pages: 18-23
• [Presentation] CXCR4-selective antagonist AMD3100 accelerates impaired wound healing in diabetic mice. (2009)
  • Author(s): Nishimura Y, Ii M, Asai J, Takenaka H, Katoh N, Hamada H, Qin G, Losordo DW, Kishimoto S.
  • Organizer: 69th Annual meeting of the Society for Investigative Dermatology(in press)
  • Place of Presentation: Montreal, Canada
  • Year and Date: 20090000
• [Presentation] Losordo DW. Hedgehog signaling promotes lymphatic differentiation of macrophages (2007)
  • Author(s): Asai J, Maruyama K, Renault M, Ii M, Takenaka H, Thorne T, Kishimoto S,
  • Year and Date: 2007-12-07
• [Presentation] Topical P2Y12 purinoreceptor antagonists reduce inflammation in irritant and allergic contact dermatitis models (2007)
  • Author(s): Katoh N, Mineoka-Tamagawa R, Nara T, Soga F, Asai J, Masuda K, Kishimoto S.
  • Year and Date: 2007-12-07
• [Presentation] 創傷治癒におけるリンパ管新生 (2007)
  • Author(s): 浅井純
  • Organizer: 第58回日本皮膚科学会中部支部学術大会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-20
• [Remarks]
  • URL: http://www.f.kpu-m.ac.jp/k/dermatol/index.htm