Research on development of hyper IgE and dermatitis through Ttc7, the regulatory factor of an autoinflammatory disease

2009 Fiscal Year Final Research Report

• Project/Area Number: 19790798
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Wakayama Medical University
• Principal Investigator: MIKITA Naoya Wakayama Medical University, 医学部, 博士研究員 (60405462)
• Project Period (FY): 2007 – 2009
• Keywords: flaky / Ttc7 / IgE / 皮膚炎

Research Abstract

Sufficient results have not been obtained by in vivo and ex vivo experiments using fsn mice, owing to MHV pollution in the SPF areas of the Wakayama Medical University Animal Facilities. Backcrossing BALB/c-fsn mice with C57BL/6 mice has been performed without revealing any obvious phenotype. On the other hand, the SNP analyses on human chronic dermatitis have shown a weak but significant association of a particular haplotype of the Ttc7a gene with psoriasis, rather than atopic dermatitis.

Research Products

• [Journal Article] 古川福実. 日本人のハンセン病発症における細菌センサー分子TLR2・DC-SIGN・NOD1・NOD2の遺伝子多型の関与 (2009)
  • Author(s): 金澤伸雄、三木田直哉、李洪錦、中谷友美、尾崎元昭、小坂眞紀、石井則久、西村泰行
  • Journal Title: 日本ハンセン病学会雑誌 78 Pages: 255-261
• [Journal Article] The protective effects of ultraviolet A1 irradiation on spontaneous lupus eryt hematosus-like skin lesions in MRL/lpr mice. (2009)
  • Author(s): Mikita N, Kanazawa N, Yoshimasu T, I keda T, Li HJ, Yamamoto Y, Furukawa F.
  • Journal Title: Clinical Developmental Immunolo gy 673952
  • Peer Reviewed
• [Journal Article] No involvement of non-synonymous TLR2 polymorphisms in Japanese lepros y patients. (2009)
  • Author(s): Mikita N, Kanazawa N, Ozaki M, Kosa ka M, Ishi N, Nishimura H, Furukawa F.
  • Journal Title: Journal of Dermatological Sc ience 54 Pages: 48-49
  • Peer Reviewed
• [Journal Article] The expression of histamine receptors in skin lesions of MRL/MP-lpr/ lpr mice. (2008)
  • Author(s): Yoshimasu T, Kanazawa N, Mikita N, Furukawa F.
  • Journal Title: Open Dermatology Journal 2 Pages: 83-86
  • Peer Reviewed
• [Presentation] MRL/lprマウスのエリテマトーデス様皮疹に対するUVA1照射の効果 (2010)
  • Author(s): 三木田直哉
  • Organizer: 第1回日本研究皮膚科学会きさらぎ塾
  • Place of Presentation: 沖縄県読谷村
  • Year and Date: 20100213-20100214
• [Presentation] The protective effects of ultraviolet A1 irradiation on spontaneous lupus erythematosus-like skin lesions in MRL/lpr mice. (2009)
  • Author(s): Furukawa F, Yamamoto Y, Mikita N, Kanazawa N, Yoshimasu T, Uede M.
  • Organizer: The 4th Asian Congress on Autoimmunity
  • Place of Presentation: シンガポール
  • Year and Date: 20090911-20090913
• [Presentation] The protective effects of ultraviolet A1 irradiation on spontaneous lupus erythematosus-like skin lesions in MRL/lpr mice. (2009)
  • Author(s): Yoshimasu T、Mikita N, Kanazawa N, Furukawa F.
  • Organizer: The 69th Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: モントリオール
  • Year and Date: 20090506-20090509
• [Presentation] MRL/lprマウスのエリテマトーデス様皮疹に対するUVA1照射の効果 (2009)
  • Author(s): 三木田直哉、李洪錦、石黒真理子、池田高治、吉益隆、金澤伸雄、山本有紀、古川福実
  • Organizer: 第108回日本皮膚科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 20090424-20090426
• [Presentation] MRL/lprマウスのエリテマトーデス様皮疹に対するUVA1照射の効果 (2009)
  • Author(s): 三木田直哉、李洪錦、石黒真理子、池田高治、吉益隆、金澤伸雄、山本有紀、古川福実
  • Organizer: 第412回日本皮膚科学会大阪地方会
  • Place of Presentation: 大阪
  • Year and Date: 20090321-20090326
• [Presentation] 日本のハンセン病における細菌センサー分子TLR2, DC-SIGN, NOD1, and NOD2の遺伝子的関与 (2008)
  • Author(s): 金澤伸雄、三木田直哉、李洪錦、中谷友美、尾崎元昭、小坂眞紀、石井則久、古川福実
  • Organizer: 第38回日本免疫学会総会・学術大会
  • Place of Presentation: 京都
  • Year and Date: 20081201-20081203
• [Presentation] MRL/lprマウスのエリテマトーデス様皮膚症に対する紫外線UVA-1治療の予防的効果の検討 (2008)
  • Author(s): 三木田直哉、李洪錦、乾匡範、池田高治、吉益隆、金澤伸雄、古川福実
  • Organizer: 第38回日本免疫学会総会・学術大会
  • Place of Presentation: 京都
  • Year and Date: 20081201-20081203
• [Presentation] MRL/lprマウスのエリテマトーデス様皮膚症に対する紫外線UVA-1治療の予防的効果の検討 (2008)
  • Author(s): 三木田直哉、李洪錦、池田高治、吉益隆、金澤伸雄、古川福実
  • Organizer: 第58回日本アレルギー学会秋期学術大会
  • Place of Presentation: 東京
  • Year and Date: 20081127-20081129
• [Presentation] アトピー性皮膚炎患者及び乾癬患者におけるTetratricopeptide repeat domain 7A遺伝子多型の検討 (2008)
  • Author(s): 三木田直哉、乾匡範、金澤伸雄、西村泰行、古川福実
  • Organizer: 第38回日本皮膚アレルギー・接触皮膚炎学会総会・学術大会
  • Place of Presentation: 大阪
  • Year and Date: 20081107-20081109
• [Presentation] Genetic involvement of bacterial sensor molecules, TLR2, DC-SIGN, NOD1 and NOD2, in Japanese leprosy. (2008)
  • Author(s): Kanazawa N, Mikita N, Li H, Nakatani N, Ozaki M, Kosaka M, Ishii N, Furukawa F.
  • Organizer: The 10th International Symposium on Dendritic Cells
  • Place of Presentation: 神戸
  • Year and Date: 20081001-20081005
• [Presentation] 細菌センサー分子TLR2・DC-SIGN・NOD2の遺伝子多型のハンセン病発症への関与 (2008)
  • Author(s): 金澤伸雄、三木田直哉、尾崎元昭、小坂眞紀、石井則久、古川福実
  • Organizer: 第20回日本アレルギー学会春期臨床大会
  • Place of Presentation: 東京
  • Year and Date: 20080612-20080614
• [Presentation] 細菌センサー分子tlr2・dc-si gn・nod2の遺伝子多型のハンセン病発症への関与 (2008)
  • Author(s): 金澤伸雄、三木田直哉、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
  • Organizer: 第81回日本ハンセン病学会総会・学術大会
  • Place of Presentation: 熊本
  • Year and Date: 20080521-20080523
• [Presentation] Analysis of the Tetratricopeptide repeat domain 7 gene polymorphisms in Japanese psoriasis and atopic dermatitis patients. (2008)
  • Author(s): Mikita N, Inui M, Kanazawa N, Nishimura H, Furukawa F.
  • Organizer: International Investigative Dermatology 2008
  • Place of Presentation: 京都
  • Year and Date: 20080514-20080517
• [Presentation] Genetic involvement of bacterial sensor molecules, TLR2, DC-SIGN and NOD2, in Hansen's disease. (2008)
  • Author(s): Kanazawa N, Mikita N, Nakatani N, Ozaki M, Kosaka M, Ishii N, Nishimura H, Furukawa F.
  • Organizer: International Investigative Dermatology 2008
  • Place of Presentation: 京都
  • Year and Date: 20080514-20080517
• [Presentation] Familial Japanese fever (Nakajo-Nishimura syndrome): a novel hereditary periodic fever with partial lipodystrophy and a search for LPIN gene mutations. (2008)
  • Author(s): Kanazawa N, Mikita N, Furukawa F, Nishimura H, Kawano S, Matsunaka M, Koike M, Sugino H.
  • Organizer: The Fifth International Congress on Familial Mediterranean Fever and Systemic Autoinflammatory Diseases
  • Place of Presentation: ローマ(イタリア)
  • Year and Date: 20080404-20080408
• [Presentation] Analysis of TLR2 gene polymorphisms in Hansen's disease. (2007)
  • Author(s): Kanazawa N, Mikita N, Ozaki M, Kosaka M, Ishii N, Nishimura H, Furukawa F.
  • Organizer: 第37回日本免疫学会総会・学術大会
  • Place of Presentation: 東京
  • Year and Date: 20071120-20071122
• [Presentation] Analysis of TLR2 gene polymorphisms in Hansen's disease. (2007)
  • Author(s): Kanazawa N, Mikita N, Ozaki M, Kosaka M, Ishii N, Nishimura H, Furukawa F.
  • Organizer: The 4th World Association of Sarcoidosis and Other Granulomatous Disorders
  • Place of Presentation: 東京
  • Year and Date: 20071019-20071020
• [Presentation] ハンセン病におけるTLR2遺伝子変異の検索 (2007)
  • Author(s): 金澤伸雄、三木田直哉、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
  • Organizer: 第80回日本ハンセン病学会総会・学術大会
  • Place of Presentation: 横浜
  • Year and Date: 20070517-20070519
• [Presentation] ハンセン病におけるTLR2遺伝子変異の検索 (2007)
  • Author(s): 三木田直哉、金澤伸雄、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
  • Organizer: 第32回日本研究皮膚科学会学術大会・総会
  • Place of Presentation: 横浜
  • Year and Date: 20070418-20070420
• [Presentation] ハンセン病におけるTLR2遺伝子変異の検索 (2007)
  • Author(s): 三木田直哉、金澤伸雄、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
  • Organizer: 第401回日本皮膚科学会大阪地方会和歌山地区会
  • Place of Presentation: 和歌山
  • Year and Date: 2007-05-26