Neural stem cell transplantation in a model of fetal alcohol effects

2008 Fiscal Year Final Research Report

• Project/Area Number: 19790822
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: YOSHINAGA Toshihiro Sapporo Medical University, 医学部, 助教 (70404704)
• Project Period (FY): 2007 – 2008
• Keywords: 脳・神経 / 神経科学 / 再生医学 / 神経幹細胞 / アルコール

Research Abstract

胎児性アルコール症候群のモデルラットに対して,ラット胎仔由来の神経幹細胞の経静脈的移植療法を施行した。その結果,胎児性アルコール症候群の主要症状である多動性と衝動性の行動異常が正常ラットと同等の程度まで改善することを明らかにした。

Research Products

• [Journal Article] Lithium-induced suppression of transcription repressor NRSF/REST: effects on the dysfunction of neuronal differentiation by ethanol. (2008)
  • Author(s): Ishii T, Hashimoto E, Ukai W, Tateno M, YYoosshhiinnaaggaa TT, Saito S, Sohma H, Saito T.
  • Journal Title: European Journal of Pharmacology. 593 Pages: 36-43
  • Peer Reviewed
• [Journal Article] アルコールによる脳神経回路障害のメカニズムとその修復法の探索神経細胞・神経幹細胞を用いたin vitro, in vivo解析 (2008)
  • Author(s): 鵜飼渉,石井貴男,吉永敏弘,館農勝,橋本恵理,小野貴文,渡邊公彦,渡邉一平,白坂智彦,齋藤利和
  • Journal Title: 日本アルコール・薬物医学会雑誌 43 Pages: 763-769
  • Peer Reviewed
• [Journal Article] アルコールによる脳障害とエピジェネティクス制御機構 (2008)
  • Author(s): 石井貴男,橋本恵理,鵜飼渉,館農勝,吉永敏弘,小野貴文,渡邊公彦,齋藤諭,齋藤利和
  • Journal Title: 日本アルコール・薬物医学会雑誌 43 Pages: 705-713
  • Peer Reviewed
• [Journal Article] アルコールによる脳神経回路網の異常神経幹細胞を用いた修復の試み (2008)
  • Author(s): 鵜飼渉,橋本恵理,吉永敏弘,石井貴男,館農勝,小野貴文,渡邊公彦,齋藤諭,齋藤利和
  • Journal Title: 日本神経精神薬理学雑誌 28 Pages: 69-73
  • Peer Reviewed
• [Journal Article] Neural stem cell transplantation in a model of fetal alcohol effects. (2007)
  • Author(s): Yoshinaga T, Hashimoto E, Ukai W, Toki S, Saito S, Saito T.
  • Journal Title: Journal of Neural Transmission 72 Pages: 331-337
  • Peer Reviewed
• [Presentation] New potential therapy of neural stem cell transplantation for repairing alcohol induced brain damage (2008)
  • Author(s): Saito T, Hashimoto E, Ukai W, Yoshinaga T, Ishii T, Tateno M, Saito S.
  • Organizer: 16th Collegium Internationale Neuro-Psychopharmacologicum
  • Year and Date: 20080713-17
• [Presentation] The common aspects of pathophysiology of alcoholism and depression (2008)
  • Author(s): Tateno M, Ukai W, Yoshinaga T, Ishii T, Saito S, Hashimoto E, Saito T.
  • Organizer: Joint Congress of 31th Annual Scientific Meeting of the Research Society on Alcoholism/14th Annual Meeting of the International Society for Biomedical Research on Alcoholism
  • Year and Date: 20080628-0702
• [Presentation] Translational research of repairing therapy for damaged brain (2008)
  • Author(s): Hashimoto E, Yoshinaga T, Ishii T, Saito S, Ukai W, Saito T
  • Organizer: Joint Congress of 31th Annual Scientific Meeting of the Research Society on Alcoholism/14th Annual Meeting of the International Society for Biomedical Research on Alcoholism
  • Year and Date: 20080628-0702
• [Presentation] The alteration of CREB/NRSF regulation in the neural stem cell dysfunction by ethanol (2008)
  • Author(s): Ukai W, Ishii T, Yoshinaga T, Tateno M, Ono T, Watanabe K, Hashimoto E, Saito S, Mukai Y, Saito T.
  • Organizer: Joint Congress of 31th Annual Scientific Meeting of the Research Society on Alcoholism/14th Annual Meeting of the International Society for Biomedical Research on Alcoholism
  • Year and Date: 20080628-0702
• [Presentation] 胎児期アルコール曝露モデルに対する神経幹細胞移植の試み (2008)
  • Author(s): 吉永敏弘,石井貴男,館農勝,小野貴文,渡邊公彦,渡邉一平,白坂知彦,齋藤諭,橋本恵理,齋藤利和
  • Organizer: 第38回日本神経精神薬理学会
  • Year and Date: 2008-10-01
• [Presentation] 精神疾患に対する幹細胞移植療法の可能性に関する研究 (2008)
  • Author(s): 鵜飼渉,吉永敏弘,石井貴男,橋本恵理,小野貴文,館農勝,渡邊公彦,渡邉一平,白坂知彦,向裕加,齋藤諭,齋藤利和
  • Organizer: 第51回日本神経化学会
  • Year and Date: 2008-09-12
• [Presentation] The effect of lithium on ethanol inhibition of neuronal differentiation : role for transcription repressor NRSF (2007)
  • Author(s): Ishii T , Ukai W, Tateno M, Yoshinaga T, Ono T, Saito S, Hashimoto E, Saito T.
  • Organizer: The 37th Annual Meeting of Society for Neuroscience
  • Year and Date: 20071103-07
• [Patent(Industrial Property Rights)] Pharmaceutical compounds containing atelocollagen and stem cells for treatment of psychiatric or neurological diseases (2007)
  • Inventor(s): 吉永敏弘
  • Industrial Property Rights Holder: 吉永敏弘
  • Industrial Property Number: 60/932753
  • Acquisition Date: 20070000
  • Overseas