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2008 Fiscal Year Final Research Report

Roles of a Thromboxane A2 Receptor, TP signaling in acute ischemia and SDF-1, VEGF expression

Research Project

  • PDF
Project/Area Number 19790979
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionKitasato University

Principal Investigator

AMANO Hideki  Kitasato University, 医学部, 助教 (60296481)

Project Period (FY) 2007 – 2008
KeywordsトロンボキサンA2 / 血管新生 / SDF-1 / VEGF / 血小板
Research Abstract

NieらはThromboxane A2が血管内皮細胞のTP受容体に作用し血管内皮細胞の遊走を促進させ腫瘍の血管新生及び転移形成を促進させると報告した(Biochemi. Biophy. Rese. Com 2000)。しかしながら、下肢虚血モデルを用いてThromboxane A2が血小板の凝集を増強させたと同時に血管新生を促進させた報告例はない。本実験で申請者は血小板凝集能の差のあるTP+/+、TP-/-で下肢虚血モデルを作成し、虚血部位の血管新生部位に血小板由来のVEGFとSDF-1が骨髄に作用しCXCR4+VEGFR1+造血前駆細胞を虚血組織に動員させ虚血の改善を増強することを明らかにした。

  • Research Products

    (5 results)

All 2009 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth.2009

    • Author(s)
      Ogawa Y, Suzuki T, Oikawa A, Hosono K, Kubo H, Amano H, Ito Y, Kitasato H, Hayashi I, Kato T, Sugimoto Y, NarumiyaS, Watanabe M, Majima M.
    • Journal Title

      Biochem Biophys Res Commun 382(4)

      Pages: 720-5

    • Peer Reviewed
  • [Journal Article] Blockade of an angiotensin type I receptor enhances effects of radiation on tumor growth and tumor-associated angiogenesis by reducing vascular endothelial growth factor expression.2009

    • Author(s)
      Ohnuma Y, Toda M, Fujita M, Hosono K, Suzuki T, Ogawa Y, Amano H, Kitasato H, Hayakawa K, Majima M.
    • Journal Title

      Biomed Pharmacother . 63(2)

      Pages: 136-45

    • Peer Reviewed
  • [Journal Article] Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide.2008

    • Author(s)
      Toda M, Suzuki T, Hosono K, Hayashi I, Hashiba S, Onuma Y, Amano H, Kurihara Y, Kurihara H, Okamoto H, Hoka S, Majima M.
    • Journal Title

      Proc Natl Acad Sci U S A. 105(36)

      Pages: 13550-5

    • Peer Reviewed
  • [Presentation] TP receptor signaling enhances angiogenesis during ischemia via P-selectin mediated adhesion of platelets to endothelial cells2009

    • Author(s)
      天野英樹
    • Organizer
      微小循環学会総会
    • Place of Presentation
      東京
    • Year and Date
      20090200
  • [Presentation] Roles of a Thromboxane A2 Receptor, TP signaling in acute ischemia and SDF-1, VEGF expression2007

    • Author(s)
      天野英樹
    • Organizer
      微小循環学会総会
    • Place of Presentation
      京都
    • Year and Date
      20070200

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Published: 2010-06-10   Modified: 2016-04-21  

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