The effect of Kampo medicine on aging related disease

2009 Fiscal Year Final Research Report

• Project/Area Number: 19791029
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Osaka University
• Principal Investigator: KISHIDA Yuki Osaka University, 医学系研究科, 寄附講座助教 (20423163)
• Project Period (FY): 2007 – 2009
• Keywords: 骨 / 軟骨代謝学 / 漢方薬

Research Abstract

Saikokaryukotsuboreito (SRB) is a traditional Japanese herbal medicine. We investigated the effect of SRB on bone metabolism in the postmenopausal period using an ovariectomized (OVX) murine model. We found that SRB can prevent loss of bone volume and suppress serum IL-6 levels in this postmenopausal model and is a promising candidate for treatment of postmenopausal osteoporosis.

Research Products

• [Journal Article] The fixed herbal drug composition "Saikokaryukotsuboreito" prevents bone loss with an association of serum IL-6 reductions in ovariectomized mice model. (2010)
  • Author(s): Hattori T, Fei W, Kizawa T, Nishida S, Yoshikawa H, Kishida Y
  • Journal Title: Phytomedicine 17(3-4) Pages: 170-7
• [Presentation] Saikokaryukotsuboreito, a traditional Japanese herbal medicine, inhibitsbone loss in the postmenopausal period via suppression of interleukin 6 (2010)
  • Author(s): Takako Hattori, Wu Fei, Takuji Kizawa, Kazunari Ozaki, Junsuke Arimitsu, Takaya Inoue, Shinji Nishida, Hideki Yoshikawa, Yuki Kishida
  • Organizer: The 15th International Congress of Oriental Medecine
  • Place of Presentation: Tokyo
  • Year and Date: 2010-02-28