Role of notochord for intervertebral disc degeneration

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19791045
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: TSUJI Takashi Keio University, 医学部, 助教 (60296639)
• Project Period (FY): 2007 – 2010
• Keywords: 椎間板 / 脊索 / 髄核 / 線維輪 / 終板

Research Abstract

椎間板変性のメカニズムには不明な点が多いが、人では脊索性髄核から線維軟骨性髄核に移行する10歳代から椎間板変性が生じることが判明している。われわれは脊索性髄核が椎間板変性に対して抑制的に働く機能を有している可能性が高いと考え、その機能について家兎椎間板を用いて、脊索性髄核の役割を組織学的、分子生物学的手法を用いて検討してきた。それらの基礎的データをもとに、臨床的データの解析を行い椎間板変性に関連する因子の同定を行う。

Research Products

• [Journal Article] Age-related changes in expression of tissue inhibitor of metalloproteinases-3 associated with transition from the notochordal nucleus pulposus to the fibrocartilaginous nucleus pulposus in rabbit intervertebral disc (2007)
  • Author(s): Tsuji T, Chiba K, Imabayashi H, Fujita Y, Hosogane N, Okada Y, et al.
  • Journal Title: Spine 32(8) Pages: 849-856
  • Peer Reviewed
• [Journal Article] 椎間板の加齢と変性 (2007)
  • Author(s): 辻崇 千葉一裕
  • Journal Title: 中山書店 20 Pages: 386-390
• [Presentation] Risk factors for radiological adjacent segment degeneration after lumbar fusion for spondylolisthesis (2010)
  • Author(s): suji Takashi, et al.
  • Organizer: ISSLS
  • Place of Presentation: Aukland
  • Year and Date: 2010-04-16
• [Presentation] Type II Collagen Gene Expression of Intervertebral Disc in Ovariectomized Rats (2008)
  • Author(s): Kato Masanori, Fujita Nobuyuki, Takaishi Hironari, Takito Jiro Kimura, Tokuhiro Kikuchi, Hosogane Naobumi, Tsuji Takashi, Matsumoto, Morio, Toyama, Yoshiaki, Chiba, Kazuhiro
  • Organizer: ORS
  • Place of Presentation: San Fancisco
  • Year and Date: 2008-03-03
• [Presentation] Expression of TIMP-3 and Aggrecanases associated with transition from notochordal nucleus pulposus to fibrocartilaginous nucleus pulposus in rabbit intervertebral disc (2007)
  • Author(s): Tsuji T, et al.
  • Organizer: ISSLS
  • Place of Presentation: Hong Kong
  • Year and Date: 2007-06-11