2010 Fiscal Year Final Research Report
Role of notochord for intervertebral disc degeneration
| Project/Area Number |
19791045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
TSUJI Takashi Keio University, 医学部, 助教 (60296639)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 椎間板 / 変性 / 髄核 / 脊索 |
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| Research Abstract |
The levels of expression of TIMP-3 in the notochordal NP were significantly lower in 160-week-old rabbits than those in 4-week-old rabbits. The decrease in the expression of TIMP-3 possibly mediated in part by TGF-β1 cause an imbalance of ADAMTS4/TIMP-3 ratio at the transition period from the notochordal to the fibrocartilaginous NP.
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Research Products
(18 results)
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[Presentation] Type II Collagen Gene Expression of Intervertebral Disc in Ovariectomized Rats.2008
Author(s)
Kato Masanori, Fujita Nobuyuki, Takaishi Hironari, Takito Jiro, Kimura Tokuhiro, Hosogane Naobumi, Tsuji, Takashi, Matsumoto, Morio, Toyama Yoshiaki, Chiba Kazuhiro.
Organizer
Annual Meeting of Orthopaedic Research Society.
Place of Presentation
San Francisco, CA USA.
Year and Date
2008-03-02
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[Presentation] Expression of TIMP-3 and Aggrecanases associated with transition from notochordal nucleus pulposus to fibrocartilaginous nucleus pulposus in rabbit intervertebral disc.2007
Author(s)
Tsuji T, Chiba K, Fujita N, Miyake A, Kato M, Watanabe K, Ishii K, Takaishi H, Nakamura M, Matsumoto M, Toyama Y.
Organizer
International Society for the study of the Lumbar Spine
Place of Presentation
Hong Kong, China.
Year and Date
2007-06-10
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