2009 Fiscal Year Final Research Report
The mechanism of cannabinoid-induced analgesic effect at the level of the spinal cord
| Project/Area Number |
19791075
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KIYA Tomohiro Sapporo Medical University, 医学部, 研究員 (10438046)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 疼痛治療学 |
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| Research Abstract |
This study focused on the cannabinoid-induced analgesic effect at the level of the spinal cord. Spinal administration of ACEA inhibited the withdrawal latency to noxious heat. Next the change of EPSC in chemotherapy-induced peripheral neuropathy model was examined using in vivo patch-clamp recording. Spontaneous EPSCs and cold stimuli-induced EPSCs increased in the neuropathy model compared to those in sham model, and they were suppressed after ACEA perfusion. The spinal administration of cannabinoids produces the analgesic effects by inhibition of EPSC.
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