Development of gene therapy for bone cancer pain

2009 Fiscal Year Final Research Report

• Project/Area Number: 19791076
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Sapporo Medical University
• Principal Investigator: NIIYAMA Yukitoshi Sapporo Medical University, 医学部, 講師 (90423764)
• Project Period (FY): 2007 – 2009
• Keywords: transient receptor vanilloid subfamily 1 / runt-related transcription factor 1 / 骨がん / 後根神経節 / 疼痛

Research Abstract

I have reported that cancer-related chemical mediators including endothelin-1 sensitize transient receptor vanilloid subfamily 1 (TRPV1), and the expression of TRPV1 in the peripheral neurons is increased, leading to bone cancer pain. However, the mechanisms underlying up-regulation of TRPV1 has been elucidated. Here, I focused on a transcriptional factor runt-related transcription factor 1(Runx1), which was expressed in the peripheral neurons, to clarify the mechanisms of up-regulation of TRPV1 in the bone cancer condition.

Research Products

• [Journal Article] Reduction of bone cancer pain by CB1 activation and TRPV1 inhibition. (2010)
  • Author(s): Kawamata T, Niiyama Y, Yamamoto J, Furuse S
  • Journal Title: J Anesth 24 Pages: 328-332
  • Peer Reviewed
• [Journal Article] Reduction of bone cancer pain by activation of spinal cannabinoid receptor 1 and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain. (2009)
  • Author(s): Furuse S, Kawamata T, Yamamoto J, Niiyama Y, Omote K, Watanabe M, Namiki A
  • Journal Title: Anesthesiology 111 Pages: 173-186
  • Peer Reviewed
• [Journal Article] SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain. (2009)
  • Author(s): Niiyama Y, Kawamata T, Yamamoto J, Furuse S, Namiki A
  • Journal Title: Brit J Anaesth 102 Pages: 251-258
  • Peer Reviewed
• [Journal Article] Involvement of TRPV1 in endothelin-1-induced pain-like behavior. (2009)
  • Author(s): Kawamata T, Wenjin J, Yamamoto J, Niiyama Y, Furuse S, Omote K, Namiki A
  • Journal Title: Neuroreport 20 Pages: 233-237
  • Peer Reviewed
• [Journal Article] Bone cancer increases transient receptor potential vanilloid subfamily 1 expression within distinct subpopulations of dorsal root ganglion. (2007)
  • Author(s): Niiyama Y, Kawamata T, Yamamoto J, Omote K, Namiki A
  • Journal Title: neuroscience 148 Pages: 560-72
  • Peer Reviewed
• [Presentation] 並木昭義骨がん疼痛におけるモルヒネおよびTRPV1拮抗薬(SB366971)の効果 (2009)
  • Author(s): 新山幸俊, 川股知之, 古瀬晋吾, 山本純
  • Organizer: 日本麻酔科学会第56回大会
  • Place of Presentation: 神戸
  • Year and Date: 20090816-20090818
• [Presentation] Analgesic effects of novel TRPV1 antagonist and its interaction with morphine in bone cancer pain. (2008)
  • Author(s): Niiyama Y, Kawamata T, Furuse S, Namiki A
  • Organizer: 12th World Congress of PAIN, Grasgow
  • Place of Presentation: Scotland, UK
  • Year and Date: 20080817-20080822
• [Presentation] Analgesic effects of a novel TRPV1 antagonist and its interaction with morphine in bone cancer pain. (2007)
  • Author(s): Niiyama Y, Kawamata T, Furuse S, Namiki A
  • Organizer: The 2007 ASA Annual Meeting, San Francisco
  • Place of Presentation: CA, USA
  • Year and Date: 20071007-20071013
• [Presentation] 骨がん性疼痛におけるTRPV1の関与 (2007)
  • Author(s): 新山幸俊, 川股知之, 山本純, 表圭一, 並木昭義
  • Organizer: 日本麻酔科学会第第54回大会
  • Place of Presentation: 札幌
  • Year and Date: 20070531-20070602