2009 Fiscal Year Final Research Report
Development of a new procedure for measurement of brain water content -aquaporin as a target of a new therapy for brain edema-
| Project/Area Number |
19791078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagoya City University |
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Principal Investigator |
HIRATE Hiroyuki Nagoya City University, 大学院・医学研究科, 助教 (20363939)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 蛋白質 / 脳・神経 / 脳神経疾患 |
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| Research Abstract |
Brain edema leading to an expansion of brain volume has a crucial impact on morbidity and mortality following brain damages. It is necessary to develop a new procedure for measurement of brain water content for experiments. Here, I have developed a new method of measurement of focal brain water content by Karl-Fischer titration. The method will be useful for studies of brain edema.
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[Journal Article] Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes.2008
Author(s)
Morisima M, Aoyama M, Iida Y, Yamamoto N, Hirate Hiroyuki, Arima H, Fujita Y, Sasano H, Tsuda T, Katsuya H, Asai K, Sobue K
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Journal Title
Neuroscience Research 61(1)
Pages: 18-26
Peer Reviewed
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