2010 Fiscal Year Final Research Report

The effect of genetic polymor phism on propofol metabolism

Research Project

Project/Area Number	19791085
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Wakayama Medical University
Principal Investigator	TOKINAGA Yasuyuki Wakayama Medical University, 医学部, 助教 (60438281)
Project Period (FY)	2007 – 2010
Keywords	遺伝子多型 / プロポフォール / 遺伝子発現 / SNP / 薬物代謝
Research Abstract	Propofol is widely using anesthetic drug. Propofol is mainly catalyzed by UDP-Glucuronosyltransferase 1A9(UGT1A9). It has been shown that several single nucleotide polymorphisms (SNPs) in regulatory region of UGT1A9 gene are associated with the expression level of UGT1A9 protein. The purpose of this study is to elucidate the relationship between these SNPs and the rate of propofol metabolism in vivo in Japanese population. The blood samples were collected from 50 persons who were living in Wakayama, Japan. Genomic DNA was prepared from each sample. Genotypes of these allele were all wild type.

(2 results)