2009 Fiscal Year Final Research Report
DNA methylation of imprinted loci in the infertile sperm andassisted conception.
| Project/Area Number |
19791131
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Fumihiko Tohoku University, 大学院・医学系研究科, 助教 (20400343)
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| Project Period (FY) |
2007 – 2009
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| Keywords | ゲノムインプリンティング / 生殖補助医療(ART) / DNAメチル化 / 乏精子症 |
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| Research Abstract |
We analyzed the methylation of the 7 imprinted genes of 97 infertile sperm and 78 miscarriage DNA specimen after various ART treatment. We found the abnormality to be 24.7%, 21.7% respectively. We found much low birth weight children after ART treatment, and by the questionary survey, the tendency that a search and a social index were low in the ART children. To evaluate safety and danger of infertility treatment using ART which is expected to increases in future,further analyses of a large number of the ART baluy.
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[Journal Article] DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm.2009
Author(s)
Hisato Kobayashi, Hitoshi Hiura, Rosalind M John, Akiko Sato, Eiko Otsu, Naoko Kobayashi, Rei Suzuki, Fumihiko Suzuki, Chika Hayashi, Takafumi Utsunomiya, Nobuo Yaegashi, Takahiro Arima
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Journal Title
European Journal of Human Genetics 12
Pages: 1582-91
Peer Reviewed
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[Presentation] Expression of estrogen receptor (ER) beta isoforms and Its correlation with DNA methylation in human epithelial ovarian cancer.2008
Author(s)
F. Suzuki1, J. Akahira, I. Miura, S. Nagase1, T. Takano, H. Niikura, T. Suzuki, K. Ito, S. Hayashi, H. Sasano, N. Yaegashi
Organizer
ASCO2008 (American Society of Clinical Oncology)
Place of Presentation
Annual Meeting Chicago
Year and Date
2008-06-01
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