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2008 Fiscal Year Final Research Report

Establishment of in vitro maturation of oocytes by using of novel ovarian paracrine factors and its clinical application

Research Project

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Project/Area Number 19791133
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionAkita University

Principal Investigator

KAWAMURA Kazuhiro  Akita University, 医学部, 助教 (10344756)

Project Period (FY) 2007 – 2008
Keywords神経栄養因子 / 卵胞発育 / 胚発育 / 着床 / 絨毛発育
Research Abstract

我々は卵の成熟に必要な因子を同定・解析してきた。本研究では、既知の全ての因子を体外で未熟卵に作用させ、体内で成熟した卵と比較して、その卵成熟の効率と遺伝子レベルでの正常性について検討した。その結果、マウスでは体内とほぼ同等の卵成熟を誘導することができた。遺伝子レベルの差違については、大きな違いを認める遺伝子はなかったが、一部の遺伝子で増減が認められ、未知の重要な因子の存在を含めさらなる検討が必要である。

  • Research Products

    (19 results)

All 2010 2009 2008 Other

All Journal Article (8 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Increasing levels of amphiregulin in follicular fruids are associated with human oocyte maturation.2010

    • Author(s)
      Sasaki M, Kawamura K, Ye Y, Kumazawa Y, Kumagai J, Tanaka T
    • Journal Title

      Akita J Med (in press)

  • [Journal Article] Leptin promotes oocyte development into preimplantation embryos and involvement of Ob-Ra/MEK signaling in the leptin mediated oocyte nuclear maturation2009

    • Author(s)
      Ye Y, Kawamura K, Sasaki M, Kawamura N, Groenen P, Gelpke MD, Kumagai J, Fukuda J, Tanaka T
    • Journal Title

      Reprod Biomed Online. 19

      Pages: 181-190

  • [Journal Article] Brain-derived neurotrophic factor promotes implantation and subsequent placental development by stimulating trophoblast cell growth and survival2009

    • Author(s)
      Kawamura K, Kawamura N, Sato W, Fukuda J, Kumagai J, Tanaka T
    • Journal Title

      Endocrinology 150

      Pages: 3774-82

  • [Journal Article] Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes2009

    • Author(s)
      Ye Y, Kawamura K, Sasaki M, Kawamura N, Groenen P, Gelpke MD, Rauch R, Hsueh AJ, Tanaka T
    • Journal Title

      Reprod Biol Endocrinol 7

      Pages: 26

  • [Journal Article] Paracrine regulation of the resumption of oocyte meiosis by endothelin-12009

    • Author(s)
      Kawamura K, Ye Y, Liang LC, Kawamura N, Gelpke MS, Rauch R, Tanaka T, Hsueh AJW
    • Journal Title

      Dev Biol 327

      Pages: 62-70

  • [Journal Article] Completion of meiosis I of preovulatory oocytes and facilitation of preimplantation embryo development by glial cell line-derived neurotrophic factor.2008

    • Author(s)
      Kawamura K, Ye Y, Kawamura N, Jing L, Groenen P, Gelpke MS, Rauch R, Hsueh AJW, Tanaka T
    • Journal Title

      Dev Biol 315

      Pages: 189-202

  • [Journal Article] Preimplantation embryo development and its regulatory factors.2008

    • Author(s)
      Kawamura K
    • Journal Title

      Akita J Med 35

      Pages: 113-122

  • [Journal Article] Regulation of oocyte maturation and preimplantation embryo development by maternal paracrine factors.2008

    • Author(s)
      Kawamura K
    • Journal Title

      Acta Obst Gynaec JPN 60

      Pages: 1778-1788

  • [Presentation] 新規母体由来卵成熟因子の同定:endothelin-1/EDNRA signaling system2009

    • Author(s)
      河村和弘, 河村七美, 田中俊誠
    • Organizer
      第50回日本哺乳動物卵子学会
    • Place of Presentation
      東京
    • Year and Date
      20090000
  • [Presentation] 新規母体由来卵成熟因子の固定:endothelin-1/EDNRA signaling system2009

    • Author(s)
      河村和弘, 熊澤由紀代, 熊谷仁, 田中俊誠
    • Organizer
      第27回日本受精着床学会総会・学術講演会
    • Place of Presentation
      京都
    • Year and Date
      20090000
  • [Presentation] 中枢神経関連生理活性物質の卵成熟・胚発育・着床への影響2009

    • Author(s)
      河村和弘
    • Organizer
      第61回日本産科婦人科学会学総会・学術講演会
    • Place of Presentation
      京都
    • Year and Date
      20090000
  • [Presentation] パラクライン・オートクライン因子による胚発育、卵成熟調節2009

    • Author(s)
      河村和弘
    • Organizer
      第61回日本産科婦人科学会学総会・学術講演会
    • Place of Presentation
      京都
    • Year and Date
      20090000
  • [Presentation] Regulation of oocyte nuclear and cytoplasmic maturation by ovarian paracrine factors.2009

    • Author(s)
      Kawamura K, KumazawaY, Kumagai J, Hsueh JW Aaron, Tanaka T
    • Organizer
      The International Ovarian Conference
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-12-05
  • [Presentation] 母体由来パラクライン因子による卵成熟および胚発育の調節2008

    • Author(s)
      河村和弘
    • Organizer
      第60回日本産科婦人科学会学総会・学術講演会
    • Place of Presentation
      神奈川
    • Year and Date
      20080000
  • [Presentation] 新規母体由来卵成熟・胚発育調節因子の同定:Glial cell-line derived neurotrophic factor(GDNF)2008

    • Author(s)
      河村和弘, 河村七美, 佐藤亘, 熊谷仁, 福田淳, 田中俊誠
    • Organizer
      第49回日本哺乳動物卵子学会
    • Place of Presentation
      名古屋
    • Year and Date
      20080000
  • [Presentation] 新規母体由来卵成熟・胚発育調節因子の同定:Glial cell-line derived neurotrophic factor(GDNF)2008

    • Author(s)
      河村和弘, 佐藤亘, 天野祐湖, 熊谷仁, 福田淳, 田中俊誠, 金森恭子, 児玉英也
    • Organizer
      第26回日本受精着床学会総会・学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      20080000
  • [Presentation] 新規母体由来卵成熟・胚発育調節因子の同定:Glial cell-line derived neurotrophic factor(GDNF)2008

    • Author(s)
      河村和弘, 佐藤亘, 熊谷仁, 福田淳, 田中俊誠, 児玉英也
    • Organizer
      第51回日本生殖医学会総会・学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      20080000
  • [Presentation] 卵成熟誘導および胚発育促進作用を示す新規因子の同定:Glial cell-line derived neurotrophic factor(GDNF)2008

    • Author(s)
      河村和弘, 河村七美, 佐藤亘, 熊谷仁, 福田淳, 田中俊誠
    • Organizer
      第13回日本生殖内分泌学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20080000
  • [Remarks] DNAマイクロアレイデータの公開

    • URL

      http://receptome.stanford.edu/edi/init/init_A.asp

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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