• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2008 Fiscal Year Final Research Report

Clarification of relationship among Environmental stress, Placental construction and fetal growth, by analysis of autophagic cell death and apoptosis

Research Project

  • PDF
Project/Area Number 19791139
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Toyama

Principal Investigator

NAKASHIMA Akitoshi  University of Toyama, 大学院医学薬学研究部, 助教 (00436792)

Project Period (FY) 2007 – 2008
Keywords生殖医学
Research Abstract

胎盤形成に重要な役割を果たす絨毛外栄養膜細胞が低酸素状態において母体への浸潤能が増加するが、その機能にオートファジーが大きく寄与することを世界に先駆けて初めて明らかにすることができた。

  • Research Products

    (12 results)

All 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (4 results)

  • [Journal Article] Granulysin Produced by Uterine Natural Killer Cells Induces Apoptosis of Extravillous Trophoblasts in Spontaneous Abortion2008

    • Author(s)
      Nakashima A, Shiozaki A, Myojo S and Saito S, et. Al.
    • Journal Title

      Am J Pathol. 173

      Pages: 653-664

    • Peer Reviewed
  • [Journal Article] Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells2008

    • Author(s)
      Hashimoto I, Koizumi K, Tatematsu M, Nakashima A, Saito S and Saiki I. et. Al.
    • Journal Title

      Eur J Cancer 44

      Pages: 1022-29

    • Peer Reviewed
  • [Journal Article] The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy2008

    • Author(s)
      Saito S, Nakashima A, Myojo-Higuma S, Shiozaki A.
    • Journal Title

      J Reprod Immunol. 77

      Pages: 14-22

    • Peer Reviewed
  • [Journal Article] Inadequate tolerance induction may induce pre-eclampsia2007

    • Author(s)
      Saito S, Sakai M, Sasaki Y, Nakashima A, Shiozaki A.
    • Journal Title

      J Reprod Immunol. 76

      Pages: 30-9

    • Peer Reviewed
  • [Journal Article] The role of the immune system in preeclampsia2007

    • Author(s)
      Saito S, Shiozaki A, Nakashima A, Sakai M, Sasaki Y.
    • Journal Title

      Mol Aspects Med. 28

      Pages: 192-209

    • Peer Reviewed
  • [Journal Article] Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance2007

    • Author(s)
      Saito S, Shiozaki A, Sakai M, Nakashima A, Shima T, Ito M.
    • Journal Title

      Semin Immunopathol. 29

      Pages: 115-22

    • Peer Reviewed
  • [Journal Article] What is the role of regulatory T cells in the success of implantation and early pregnancy?2007

    • Author(s)
      Saito S, Shima T, Nakashima A, Shiozaki A, Ito M, Sasaki Y.
    • Journal Title

      J Assist Reprod Genet. Sep; 24(9)

      Pages: 379-86

    • Peer Reviewed
  • [Journal Article] Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer2007

    • Author(s)
      Nakamura T, Shima T, Saeki A, Hidaka T, Nakashima A, Saito S, et. Al.
    • Journal Title

      Cancer Sci. 98(6)

      Pages: 874-81

    • Peer Reviewed
  • [Presentation] Autophagy, bulk degradation system, promotes extravillous trophoblast invasion in low nutrient, hypoxia or hypoglycemic condition2008

    • Author(s)
      Tatematsu M, Nakashima A, Saito S.
    • Organizer
      13th IFPA meeting 2008
    • Place of Presentation
      Seggau Castle, Austria
    • Year and Date
      20080910-13
  • [Presentation] オートファジーにより低酸素下、低栄養下の絨毛外栄養細胞の浸潤能は亢進する (Good presentation賞)2008

    • Author(s)
      立松美樹子, 中島彰俊, 斎藤滋
    • Organizer
      第60回日本産科婦人科学会
    • Place of Presentation
      横浜
    • Year and Date
      20080412-15
  • [Presentation] Autophagy, bulk degradation system, promotes extravillous trophoblast invasion in low nutrient, hypoxia or hypoglycemic condition (相馬賞)2007

    • Author(s)
      Nakashima A, Tatematsu M, Saito S.
    • Organizer
      第14回世界絨毛性疾患会議
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      20071111-14
  • [Presentation] Autophagy, bulk degradation system, promotes extravilous trophoblast invasion in low nutrient, hypoxia or hypoglycemic condition2007

    • Author(s)
      Tatematsu M, Nakashima A, Saito S.
    • Organizer
      IFPA meeting 2007
    • Place of Presentation
      Kingston, Canada
    • Year and Date
      20070817-22

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi