Function of thymidylate synthase as a therapeutic target in head and neck cancer

2008 Fiscal Year Final Research Report

• Project/Area Number: 19791182
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: International University of Health and Welfare (2008); Hirosaki University (2007)
• Principal Investigator: MARUYA Shinichiro International University of Health and Welfare, 大学病院, 講師 (90396408)
• Project Period (FY): 2007 – 2008
• Keywords: 頭頸部癌 / 腺様嚢胞癌 / thymidylate synthase

Research Abstract

頭頸部癌細胞においてthymidylate synthaseの発現抑制が癌細胞の増殖を有意に抑制することが明らかとなった。

Research Products

• [Journal Article] Differential expression of topoisomerase IIα protein in salivary gland carcinomas: histogenetic and prognostic implications. (2009)
  • Author(s): Maruya S, Shirasaki T, Nagaki T, Kakehata S, Kurotaki H, Mizukami H, Shinkawa H.
  • Journal Title: BMC Cancer (in press)
• [Journal Article] Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma. (2008)
  • Author(s): Shirasaki T, Maruya S, Mizukami H, Kakehata S, Kurotaki H, Yagihashi S, Shinkawa H.
  • Journal Title: BMC Cancer (in press)
• [Journal Article] Autologous serum eardrops therapy with a chitin membrane for closing tympanic membrane perforations (2008)
  • Author(s): Kakehata S, Hirose Y, Kitani R, Futai K, Maruya S, Ishii K, Shinkawa H.
  • Journal Title: Otol Neurotol 29 Pages: 791-795
• [Journal Article] Simvastatin inactivates β1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. (2007)
  • Author(s): Takeda I, Maruya S, Shirasaki T, Mizukami H, Takahata T, Myers JN, Kakehata S, Yagihashi S, Shinkawa H.
  • Journal Title: Cancer Sci 98 Pages: 890-899
• [Journal Article] Developmental expression of the outer hair cell moter prestin in the mouse (2007)
  • Author(s): Abe T, Kakehata S, Kitani R, Maruya S, Navaratnam D, Santos-Sacchi J, Shinkawa H.
  • Journal Title: L Membr Biol 215 Pages: 49-56