New drug delivery into inner ear ; possibility of the treatment withnano technology

2009 Fiscal Year Final Research Report

• Project/Area Number: 19791184
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Tohoku University
• Principal Investigator: YAMAUCHI Daisuke Tohoku University, 大学院・医学系研究科, 非常勤講師 (70361102)
• Project Period (FY): 2007 – 2009
• Keywords: 耳鼻咽喉科学 / ナノバイオ

Research Abstract

Nano particle was examined for the potential of drug delivery to inner ear. Qdot 655 was conjugated respectively with several peptides which are horseradish peroxidase(HRP), Galectin-1, L-Glutamin Acid and epidermal growth factor(EGF). When Qdot was injected into scala media of the cochlea in guinea pig, Qdots with Galectin 1 and EGF were introduced into organ of Corti and Reissner's membrane. Nano particle is expected as treatment for inner ear disease.