2009 Fiscal Year Final Research Report

The relationship between the gene expression profile and the type of hearing impairment.

Research Project

Project/Area Number	19791202
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Shinshu University
Principal Investigator	SUZUKI Nobuyoshi Shinshu University, 医学部附属病院, 助教 (20377641)
Research Collaborator	USAMI Shinichi 信州大学, 医学部, 教授 (10184996) HASHIMOTO Shigenari 信州大学, 医学部附属病院, 助教 (90359729) NISHIO Shinya 信州大学, 医学部附属病院, 研究員 (70467166)
Project Period (FY)	2007 – 2009
Keywords	高音障害型難聴 / 老人性難聴 / 遺伝子発現パターン / SAM / レーザーマイクロダイセクション
Research Abstract	Many hearing impairments are known to be caused by genetic factor. Heareditary hearing loss contributes to the various type of hearing impairments. However, little is known about what lead to such many different phenotypes. And now, it is generally accepted that the importance of the searching another responsible genes for auditory disturbance or the identification with the localization of transcription products. We hypothesized that the variety of phenotypes are caused by not only distribution of products but also the differences in the pattern of the gene expression. We attempted to identify the gene expression analysis in the cochlea by using Real-Time PCR with laser micro dissection system and the DNA microarray analysis with using the model mouse for age-related hearing impairment.