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2008 Fiscal Year Final Research Report

Regeneration of Inner Ear Hair Cells Through Activation of BMP Signaling

Research Project

  • PDF
Project/Area Number 19791207
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKyoto University

Principal Investigator

SAKAMOTO Tatsunori  Kyoto University, 医学研究科, 助教 (60425626)

Project Period (FY) 2007 – 2008
Keywords内耳再生 / 有毛細胞 / BMP-4 / 感音難聴
Research Abstract

ほ乳類では内耳有毛細胞はいったん傷害されると再生することがない。BMP-4は有毛細胞の発生に関わる重要な因子である。本研究ではBMPシグナルの操作による有毛細胞再生の可能性について検討した。BMP-4、Nogginなどは発生中の内耳での発現が確認され、耳胞培養系では培養条件を確立、有毛細胞の評価型として用いることが出来ることを確認した。

  • Research Products

    (14 results)

All 2009 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results) Book (1 results)

  • [Journal Article] Prostaglandin E Receptor Subtype EP4 Agonist Protects Cochleae Against Noise-Induced Trauma Neuroscience2009

    • Author(s)
      Hori R, Nakagawa T, Sugimoto Y, Sakamoto T, Yamamoto N, Hamaguchi, K, Ito J.
    • Journal Title

      Neuroscience

    • Peer Reviewed
  • [Journal Article] Potential of embryonic stem cell-derived neurons for synapse formation with auditory hair cells.2008

    • Author(s)
      Matsumoto M, Nakagawa T, Kojima K, Sakamoto T, Fujiyama F, Ito J.
    • Journal Title

      J Neurosci Res. 86

      Pages: 2075-85

    • Peer Reviewed
  • [Journal Article] Surgical Invasiveness of Cell ORL J Otorhinolaryngol Relat Spec. Transplantation into the Guinea Pig2008

    • Author(s)
      Ogita H, Nakagawa T, Lee KY, Inaoka T, Okano T, Kikkawa YS, Sakamoto T, Ito J.
    • Journal Title

      Cochlear Modiolus 71

      Pages: 31-39

    • Peer Reviewed
  • [Journal Article] Ladher RKHair cell differentiation becomes tissue specific by E9.5 in mouse inner ear.2007

    • Author(s)
      Sakamoto T, Ito J
    • Journal Title

      Neuroreport 18(9)

      Pages: 841-4

    • Peer Reviewed
  • [Journal Article] JPharmacological inhibition of Notch signaling in the mature guinea pig cochlea2007

    • Author(s)
      Hori R, Nakagawa T, Sakamoto T, Matsuoka Y, Takebayashi S, Ito
    • Journal Title

      Neuroreport 18(18)

      Pages: 1911-14

    • Peer Reviewed
  • [Presentation] Treatment of Tinnitus by Lidocaine Using Inner Ear Drug Delivery2009

    • Author(s)
      Sakamoto T, Horie R, Nakagawa T, Tabata Y, Ito J.
    • Organizer
      ARO 2009 MidWinter Meeting
    • Place of Presentation
      Baltimore
    • Year and Date
      2009-02-14
  • [Presentation] Efficacy of Stealth Nano-Particles Encapsulating Betamethasone for Attenuation of Noise Induced Hearing Loss in Mice.2009

    • Author(s)
      Horie RT, Sakamoto T, Nakagawa T, Ito J.
    • Organizer
      ARO 2009 MidWinter Meeting
    • Place of Presentation
      Baltimore
    • Year and Date
      2009-02-14
  • [Presentation] Inner Ear Therapies Against Hearing Impairment and Tinnitus Using Inner Ear Drug Delivery Systems.2008

    • Author(s)
      Sakamoto T, Nakagawa T, Horie R, Ito J, Tabata Y, Ishiara T, Higaki M.
    • Organizer
      Conference on Cell Replacement in the Inner Ear
    • Place of Presentation
      Bethesda
    • Year and Date
      20080613-15
  • [Presentation] Inner Ear Regeneration by Induced Pluripotent Stem (iPS) Cells.2008

    • Author(s)
      Sakamoto T, Nishimura K, Inaoka T, Nakagawa T, Ito J.
    • Organizer
      45th Inner Ear Biology Workshop (IEB2008).
    • Place of Presentation
      Ferrara
    • Year and Date
      2008-09-21
  • [Presentation] 耳胞のパターニングに対する後脳の役割2007

    • Author(s)
      坂本達則, 中川隆之, 伊藤壽一
    • Organizer
      第17回日本耳科学会総会・学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      20071018-20
  • [Presentation] Hair cell differentiation becomes tissue specific by E9.5 in mouse inner ear2007

    • Author(s)
      Tatsunori Sakamoto, Juichi Ito, Raj Ladher.
    • Organizer
      44th Inner Ear Biology Workshop
    • Place of Presentation
      LONDON
    • Year and Date
      20070917-19
  • [Presentation] Pharmacological inhibition of Notch signaling in damaged cochleae of guinea pigs.2007

    • Author(s)
      Sakamoto T, Nakagawa T, Hori R, Matsuoka Y, Takebayashi S, Ito J.
    • Organizer
      Age Related Hearing Impairment, International Congress 2007
    • Place of Presentation
      アントワープ
    • Year and Date
      2007-06-17
  • [Presentation] 耳胞のパターニングに対する後脳の役割2007

    • Author(s)
      坂本達則, ラージ・ラダ, 伊藤壽一.
    • Organizer
      第108回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      金沢
    • Year and Date
      2007-05-17
  • [Book] 再生医療へ進む最先端の幹細胞研究 第2章8 内耳障害に対する細胞, 「移植治療」2008

    • Author(s)
      坂本達則
    • Publisher
      羊土社

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Published: 2010-06-10   Modified: 2016-04-21  

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