2008 Fiscal Year Final Research Report
Identification and differentiation induction of M cell in human nasal epithelial cells: a unique and new target for DDS
| Project/Area Number |
19791218
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
GO Mitsuru Sapporo Medical University, 医学部, 助教 (80448604)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 耳鼻咽喉学 |
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| Research Abstract |
ヒト咽頭扁桃(adenoid)上皮は,発達したタイト結合による上皮バリア機能を有し,外来病原体に対する生体防御の役割を担っていることが考えられる.そこで,我々はcytokeratin 20 (Ck20)をマーカーとして,ヒト咽頭扁桃(adenoid)におけるM細胞の同定をし,in vivoおよびin vitroでのタイト結合蛋白の発現を調べた.
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[Journal Article] PKC enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation.2008
Author(s)
Koizumi J, Kojima T, Ogasawara N, Kamekura R, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N.
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Journal Title
Peer Reviewed
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[Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.2008
Author(s)
Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J, Kamekura R, Murata M, Tanaka S, Chiba H, Himi T, Sawada N.
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Journal Title
J Mol Histol. 39(3)
Pages: 265-273
Peer Reviewed
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