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2008 Fiscal Year Final Research Report

Hearing disorder in osteoporotic and osteopetrotic mice

Research Project

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Project/Area Number 19791234
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKeio University

Principal Investigator

KANZAKI Sho  Keio University, 医学部, 助教 (50286556)

Research Collaborator MATSUO Koichi  慶應義塾大学, 医学部, 准教授 (40229422)
Project Period (FY) 2007 – 2008
Keywords聴覚 / 耳小骨 / 骨代謝
Research Abstract

破骨細胞が増加しているOpgKOマウス(骨粗鬆症マウス)は難聴を呈するが、骨粗鬆症薬を投与し形態、機能ともに予防させた。また破骨細胞が減少している大理石病モデルマウスでも難聴があることを見いだした。この結果、骨粗鬆症を有する難聴者に対して骨粗鬆症薬を投与する臨床研究を開始している。

  • Research Products

    (27 results)

All 2009 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (10 results) Book (2 results)

  • [Journal Article] Cost-effectiveness of Different Treatment Modalities for Seasonal Allergic Rhinitis in Japan-Comparison of Laser Treatment with Subcutaneous Immunotherapy and Oral2009

    • Author(s)
      Taniguchi Y , Ohshiro T, Fujii S, Ohshiro T, Sasaki K, Suzuki T, Kanzaki S, Ogawa K
    • Journal Title

      Medication-Laser therapy (in press)

    • Peer Reviewed
  • [Journal Article] Bisphosphonate Therapy Ameliorates Hearing Loss in Mice Lacking Osteoprotegerin2009

    • Author(s)
      Kanzaki S, Takada Y, Ogawa K, Matsuo K
    • Journal Title

      J Bone Miner Res 24(1)

      Pages: 43-9

    • Peer Reviewed
  • [Journal Article] Pathogenesis of hearing loss from the point of view of the long-term prognosis of steroid-dependent sensorineural hearing loss2009

    • Author(s)
      Kanzaki J, Kanzaki S, Ogawa K
    • Journal Title

      Audiol Neurotol 14(1)

      Pages: 26-34

    • Peer Reviewed
  • [Journal Article] Detection system for transplanted bone marrow stem cell in inner ear by SPIO2008

    • Author(s)
      Yamashita D, Watada Y, Kanzaki S, Toyoda M, Tanimoto N, Kobayashi M, Ogawa K, Umezawa A
    • Journal Title

      Neurosci Res

      Pages: S25

    • Peer Reviewed
  • [Journal Article] Bone marrow stem cells therapy for cochlear hair cell and auditory function2008

    • Author(s)
      Kanzaki S ,Yamashita D, Toyoda M, Kobayashi M, Ogawa K, Umezawa A
    • Journal Title

      Neurosci Res

      Pages: S25

    • Peer Reviewed
  • [Journal Article] Inferior meatal antrostomy impairs dynamic stability of the orbital walls2008

    • Author(s)
      Nagasao T, Miyamoto J, Tamaki T, Kanzaki S, Ogawa K
    • Journal Title

      Auris Nasus Larynx Nov.12(Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Ogawa K.GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease2008

    • Author(s)
      Masuda M, Tanaka K, Kanzaki S, Wakabayashi K, Oishi N, Suzuki T, Ikenaka K
    • Journal Title

      Neurosci Res 62(1)

      Pages: 15-24

    • Peer Reviewed
  • [Journal Article] Mucoepidermoid carcinoma of the head and neck : clinical analysis of 43 patients2008

    • Author(s)
      Ozawa H, Tomita T, Sakamoto K, Tagawa T, Fujii R, Kanzaki S, Ogawa K, Kameyama K, Fujii M
    • Journal Title

      Jpn J Clin Oncol 38(6)

      Pages: 414-418

    • Peer Reviewed
  • [Journal Article] Neuroprotective effects of T-817MA against noise-induced hearing loss2008

    • Author(s)
      Yamashita D, Shiotani A, Kanzaki S, Nakagawa M, Ogawa K
    • Journal Title

      Neurosci Res 61(1)

      Pages: 61(1)

    • Peer Reviewed
  • [Journal Article] In vivo delivery of adeno-associated virus was successfully and noninvasively transferred into the upporting cells of the neonatal mouse cochlea2008

    • Author(s)
      Iizuka T, Kanzaki S, Mochizuki H, Inoshita A, Narui Y, Furukawa M, Ogawa K, Ikeda K
    • Journal Title

      Human gene ther 19(4)

      Pages: 384-390

    • Peer Reviewed
  • [Journal Article] Bcl-2 genes regulate noise-induced hearing loss2008

    • Author(s)
      Yamashita D, Minami SB, Kanzaki S, Ogawa K, Miller JM
    • Journal Title

      J Neurosci Res 86(4)

      Pages: 920-928

    • Peer Reviewed
  • [Journal Article] Standardised method of selecting surgical approaches to benign parapharyngeal space tumours, based on pre-operative images2007

    • Author(s)
      Kanzaki S, Nameki H
    • Journal Title

      J Laryngol Otol 26

      Pages: 26

    • Peer Reviewed
  • [Journal Article] Development of solitary plasmacytoma in the internal auditory canal and inner ear after allogeneic hematopoietic stem cell transplantation for plasma cell leukemia2007

    • Author(s)
      Masuda M, Inoue Y, Tanosaki R, Kanzaki S, Ogawa K
    • Journal Title

      Japanese Journal of Clinical Oncology 37(9)

      Pages: 701-703

    • Peer Reviewed
  • [Journal Article] Sendai Virus Vector-Mediated Transgene Expression in the Cochlea in vivo2007

    • Author(s)
      Kanzaki S, Shiotani A, Inoue M, Hasegawa M, Ogawa K
    • Journal Title

      Audiology and Neurotology 12

      Pages: 119-126

    • Peer Reviewed
  • [Journal Article] Cholesterol granuloma surrounding the endolymphatic sac2007

    • Author(s)
      Kanzaki S, Araki Y, Okamoto Y, Kurita A, Ogawa K
    • Journal Title

      Auris Nasus larynx 34(1)

      Pages: 95-100

    • Peer Reviewed
  • [Presentation] Noninvasive in vivo delivery of transgene via adeno-associated virus into supporting cells of the neonatal mouse cochlea2009

    • Author(s)
      Iizuka T, Kanzaki S, Ogawa K
    • Place of Presentation
      ARO,Baltimore
    • Year and Date
      2009-02-16
  • [Presentation] New otoendoscopy with catheter for inner ear drug delivery2008

    • Author(s)
      Kanzaki S, Ogawa K
    • Organizer
      (poster) the American Academy of Otolaryngology-Head and Neck Surgery Foundation
    • Place of Presentation
      Washington Metro Convention Center, USA
    • Year and Date
      20080915-20
  • [Presentation] The role of inflammation and apoptosis in sudden sensorineural hearing loss(oral)2008

    • Author(s)
      Ogawa K, Kanzaki S, Okamoto Y, Fujioka M, Matsunaga T
    • Organizer
      Collegium, Oto-Rhino- Laryngologicum, Amicitiae sacrum
    • Place of Presentation
      Berlin,Germany
    • Year and Date
      20080824-27
  • [Presentation] Gene and cell delivery into nner ear2008

    • Author(s)
      Kanzaki S
    • Organizer
      Keio Medical society meeting (oral)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-10-14
  • [Presentation] Bone marrow stem cells therapy for cochlear hair cell and auditory neuron Symposia"Regeneration of Sensory Cells in the Inner Ear-From Bench to Bedside-"2008

    • Author(s)
      Kanzaki S, Yamashita D, Ogawa K
    • Organizer
      (oral) 31st Annual meeting Japan Neuroscience society meeting
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-07-11
  • [Presentation] Bisphosphonate therapy ameliorates bone resorption and hearing loss in mice lacking osteoprotegerin2008

    • Author(s)
      Kanzaki S, Ogawa K
    • Organizer
      (oral), 8th Cholesteatoma and Ear Surgery meeting
    • Place of Presentation
      Antalya, Turkey
    • Year and Date
      2008-06-17
  • [Presentation] Does Osteoporosis Affect Morphology of Otoconia2008

    • Author(s)
      Kanzaki S, Ogawa K
    • Organizer
      (oral) XXV Barany society meeting
    • Place of Presentation
      Kyoto Japan
    • Year and Date
      2008-04-02
  • [Presentation] Otosclerosis : Basic and clinical aspect2007

    • Author(s)
      Ogawa K, Inoue Y, Saito H, Kanzaki S
    • Organizer
      (oral), Collegium, Oto-Rhino-Laryngologicum, Amicitiae sacrum
    • Place of Presentation
      Seoul,Korea
    • Year and Date
      20070826-29
  • [Presentation] Bisphosphonate Therapy Ameliorates Hearing Loss Due to Osteopenia in Mice Lacking Osteoprotegerin2007

    • Author(s)
      Kanzaki S, Ito M, Ogawa K, Matsuo K
    • Organizer
      2007 Association for Research in Otolaryngology MidWinter Meeting, Session D9 : Middle Ear 1
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      20070211-15
  • [Presentation] Preventing auditory bone resorption & gene and cell herapy(invited speaker)招待講演, seminar in Massachusetts Eye and Ear Infirmary Department of Otolaryngology2007

    • Author(s)
      Kanzaki S
    • Organizer
      Harvard University
    • Place of Presentation
      Boston, USA
    • Year and Date
      2007-09-20
  • [Book] 家庭の医学、小学館2009

    • Author(s)
      神崎晶、外耳炎、外耳道湿疹
    • Total Pages
      1121-1123
    • Publisher
      小川郁編
  • [Book] (全編編集協力者)ステッドマン医学辞書(第6版)2008

    • Author(s)
      神崎晶
    • Publisher
      メジカルビュー社

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Published: 2010-06-10   Modified: 2012-09-10  

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