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2009 Fiscal Year Final Research Report

Identification of expression and localization of osteoclast-specific ABC transporters

Research Project

  • PDF
Project/Area Number 19791361
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionTokyo Institute of Technology

Principal Investigator

NAKAGAWA Hiroshi  Tokyo Institute of Technology, 大学院・生命理工学研究科, 助教 (40397039)

Project Period (FY) 2007 – 2009
Keywords口腔生化学 / 破骨細胞 / ABCトランスポーター
Research Abstract

The expression of nine and four of 49 ABC transporters were found to be up- and down-regulated during osteoclastgenesis, respectively. It was also found that the expression levels and distribution of ABCG2 were regulated by single nucleotide polymorphisms and posttranslational modifications, which was awarded the Special ABC2010 Poster Recognition Award.

  • Research Products

    (13 results)

All 2010 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results)

  • [Journal Article] Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of human ATP-binding cassette transporter ABCG2.2009

    • Author(s)
      Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., Ishikawa, T.
    • Journal Title

      FEBS J. 276

      Pages: 7237-7252

    • Peer Reviewed
  • [Journal Article] Quality control of human ABCG2 protein in the endoplasmic reticulum: Ubiquitination and proteasomal degradation.2009

    • Author(s)
      Wakabayashi-Nakao, K., Tamura, A., Furukawa, T, Nakagawa, H., Ishikawa, T.
    • Journal Title

      Advanced Drug Delivery Reviews 61

      Pages: 66-72

    • Peer Reviewed
  • [Journal Article] Major SNP (Q141K) Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations.2009

    • Author(s)
      Furukawa T, Wakabayashi K, Tamura A, Nakagawa, H., Morishima Y, Osawa Y, Ishikawa T
    • Journal Title

      Pharm. Res. 26

      Pages: 469-479

    • Peer Reviewed
  • [Journal Article] Evidence for ubiquitin-mediated proteasomal degradation of non-synonymous SNP Variants.2008

    • Author(s)
      Nakagawa, H., Tamura, A., Wakabayashi, K., Hoshijima, K., Komada, M., Yoshida, T., Kometani, S., Matsubara, T., Mikuriya, K., Ishikawa, T.
    • Journal Title

      Biochemical J. 411

      Pages: 623-631

    • Peer Reviewed
  • [Presentation] The impacts of posttranslational modifications and non-synonymous SNPs on the protein stability of human ABC transporter ABCG2 protein in culture cells2010

    • Author(s)
      Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., Furukawa, T., Ishikawa, T
    • Organizer
      The FEBS-ABC2010 - 3rd FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases
    • Place of Presentation
      インスブルック(オーストリア)
    • Year and Date
      20100227-20100305
  • [Presentation] Monomeric non-glycosylated form of human ATP-binding cassette transporter ABCG2 is the most fragile in culture cells2009

    • Author(s)
      Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., Ishikawa, T
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
  • [Presentation] N-linked glycosylation stabilizes the de novo synthesized human ABC transporter ABCG2 protein2009

    • Author(s)
      Nakagawa, H., Wakabayashi, K., Tamura, A., Koshiba, S., Toyoda, Y., Ishikawa
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
  • [Presentation] The impact of N-linked glycosylation on the protein stability of human ABC transporter ABCG2 protein2009

    • Author(s)
      Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., Ishikawa, T
    • Organizer
      2nd DKFZ-NCC Workshop on Cancer Research Tokyo
    • Place of Presentation
      東京
    • Year and Date
      2009-07-08
  • [Presentation] Genetic polymorphisms of human ABCG2 and ER-associated degradation (ERAD) pathway2008

    • Author(s)
      Wakabayashi, K., Tamura, A., An, R., Hoshijima, K., Nakagawa, H., Ishikawa, T
    • Organizer
      2nd FEBS Special Meeting Co-sponsored by FEMS ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases
    • Place of Presentation
      インスブルック(オーストリア)
    • Year and Date
      20080303-20080306
  • [Presentation] Impact of Major Non-synonymous SNP (Q141K) on Proteolysis of Human ABC Transporter ABCG2 via Lysosomal and Ubiquitin-mediated Proteasomal Degradation Pathways2008

    • Author(s)
      古川朋佳, 若林香菜子, 田村藍, 中川大, 石川智久
    • Organizer
      日本分子生物学会・日本生化学会合同大会(BMB2008)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
  • [Presentation] Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of human ATP-binding cassette transporter ABCG22008

    • Author(s)
      中川大, 若林香菜子, 田村藍, 小柴梢子, 豊田優, 石川智久
    • Organizer
      日本分子生物学会・日本生化学会合同大会(BMB2008)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
  • [Presentation] Evidence for ubiquitination and degradation of non-synonymous SNP proteins of human ATP-binding cassette transporter ABCG22007

    • Author(s)
      Nakagawa, H., Tamura, A., Wakabayashi, K., Ishikawa, T
    • Organizer
      日本分子生物学会・日本生化学会合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
  • [Presentation] ヒトABCトランスポーターABCG2のタンパク質品質管理と細胞内分解機構:一塩基多型と翻訳後修飾の影響2007

    • Author(s)
      中川大, 若林香菜子, 田村藍, 星島一幸, 石川智久
    • Organizer
      トランスポーター研究会関東支部会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-10

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Published: 2011-06-18   Modified: 2016-04-21  

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