2010 Fiscal Year Final Research Report
Analysis of thermo-sensitive nociceptor expression and mechanism by using dentin-pulp complex culture system.
| Project/Area Number |
19791404
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Conservative dentistry
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
TATSUYAMA Shoko Kagoshima University, 医学部・歯学部附属病院, 助教 (70347095)
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Keywords | 象牙芽歯髄複合体 / 温度感受性受容体 |
|---|
| Research Abstract |
In this study, we confirmed the expression of the transient receptor potential melastatin-8 (TRPM8) in human dental pulp cells and in mouse odontoblasts. Using rat dental pulp slice culture as a dentin-pulp complex models we further revealed TRPM8 expression in rat odontoblasts. Our results indicated that odontoblasts could directly respond to noxious stimuli, example as cold condition, and transduce the signal to the nearby nerves, accordingly odontblasts may be involved in dentin hypersensitivity.
|
Research Products
(1 results)
