2009 Fiscal Year Final Research Report
Analysis of NFAT signaling of osseous cells of iso-grafted bonetreated with topical administration of immunosuppressant agent.
| Project/Area Number |
19791485
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
HIROTAN Hiroaki Tohoku University, 病院, 助教 (90312595)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 口腔外科学一般 |
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| Research Abstract |
The present study was undertaken to analyze NFAT signaling of osseous cells of iso-grafted bone treated with topical administration of immunosuppressant drug, cyclosporine A. The iso-grafted bone was dissected and taken by soft X-ray. Topical cyclosporine A had no effect on bone mineral content. Topical cyclosporine A decreased the number of osteoclast and osteoblast. These results suggest that topical cyclosporine A decreased bone turnover of iso-grafted bone and another data suggest that NFAT is involved in Fas-mediated apoptosis of osseous cells.
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