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2008 Fiscal Year Final Research Report

Identification of new oral cancer biomarker through the screening ofsecreted and cell surface protein

Research Project

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Project/Area Number 19791521
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionHiroshima University

Principal Investigator

MITANI Yoshitsugu  Hiroshima University, 病院, 歯科診療医 (30432678)

Project Period (FY) 2007 – 2008
Keywords悪性腫瘍 / 新規癌バイオマーカー / 分泌蛋白質 / 膜蛋白質
Research Abstract

分泌蛋白質もしくは膜蛋白質はがんにおいて重要な役割を果たしており、診断マーカーや分子標的治療となりうる可能性を持っている。本研究はこの分泌蛋白質、膜蛋白質のみに限定したスクリーニング法を利用し、新規口腔癌バイオマーカーの同定を試みた。今回残念ながら新規マーカーの同定には至らなかったが、いくつかの膜蛋白、分泌蛋白が得られた。今後継続して研究を行うことで、新規癌マーカーが得られると考えられた。

  • Research Products

    (3 results)

All 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Expression of epiregulin,a novel epidermal growth factor ligand associated with prognosis in humanoral squamous cell carcinomas2008

    • Author(s)
      Shigeishi H, Higashikawa K, Hiraoka M, Fujimoto S, Mitani Y, Ohta K, TakechiM, Kamata N
    • Journal Title

      OncolRep 19(6)

      Pages: 1557-1564

    • Peer Reviewed
  • [Journal Article] Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy2007

    • Author(s)
      Mitani Y, Oue N, Matsumura S, Yoshida K, Noguchi T, Ito M, Tanaka S, Kuniyasu H, Kamata N, Yasui W
    • Journal Title

      Oncogene 26(30)

      Pages: 4383-4393

    • Peer Reviewed
  • [Journal Article] DNA demethylation of vascular endothelial growth factor-C is associated with gene expression and its possible involvement of lymphangiogenesis in gastric cancer2007

    • Author(s)
      Matsumura S, Oue N, Mitani Y, Kitadai Y, Yasui W
    • Journal Title

      Int J Cancer 120(8)

      Pages: 1689-1695

    • Peer Reviewed

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Published: 2010-06-10   Modified: 2016-04-21  

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