2009 Fiscal Year Final Research Report
The involvement of Ephrin signaling in the invasion and metastas is of squamous cell carcinoma cells
| Project/Area Number |
19791528
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kochi University |
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Principal Investigator |
SASABE Eri Kochi University, 教育研究部・医療学系, 助教 (40363288)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 癌 / 遺伝子 / 細胞 / 組織 / 発現制御 / シグナル伝達 |
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| Research Abstract |
Eph/Ephrin mRNA and protein were expressed in oral squamous cell carcinoma (OSC) cells. EphrinB2 was especially overexpressed in oral squamous cell carcinoma and high invasive OSC cells. The proliferation, attachment, and invasion were suppressed in EphrinB2 knock-downed cells as compared with control cells. The treatment with EphB/Fc chimera promoted the attachment, but inhibited the invasion of EphrinB2 knock-downed cells. these results suggest that EphrinB2 contributes to the proliferation, attachment, and invasion of OSC cells.
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