Elucidation of immune escape mechanisms by periodontopathic bacteria

2008 Fiscal Year Final Research Report

• Project/Area Number: 19791610
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: HONDA Tomoyuki Niigata University, 医歯学系, 特任助教 (30447635)
• Research Collaborator: DOMON Hisanori 新潟大学, 大学院医歯学総合研究科, 研究員 ; TAKAHASHI Naoki 新潟大学, 大学院医歯学総合研究科, 大学院生
• Project Period (FY): 2007 – 2008
• Keywords: 歯周病原細菌 / Porphyromonas gingivalis / IRAK-M / マクロファージ

Research Abstract

歯周病原因細菌の1つPorphyromonas gingivalis は,免疫による排除機構から逃れ,感染を慢性化させている可能性が考えられる.この細菌のもつ病原因子が歯周組織の構成細胞(マクロファージ,上皮細胞)によって認識される過程においてIRAK-M の発現が高まる.IRAK-M は免疫を抑制する分子の一つとして既に知られているが,歯周組織の細胞においても免疫応答性を低下させ,感染を慢性化させるメカニズムの一端が明らかとなった.

Research Products

• [Journal Article] Up-regulation of the endoplasmic reticulum stress-response in periodontal disease (2009)
  • Author(s): Domon H, Takahashi N, Honda T, Nakajima T, Tabeta K, Abiko Y, Yamazaki K
  • Journal Title: Clin Chim Acta 40 Pages: 134-140
  • Peer Reviewed
• [Journal Article] Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease (2008)
  • Author(s): Honda T, Aoki Y, Takahashi N, Maekawa T, Nakajima T, Ito H, Tabeta K, Okui T, Kajita K, Domon H, Yamazaki K
  • Journal Title: Clin Chim Acta 395 Pages: 137-141
  • Peer Reviewed
• [Journal Article] Early and preferential induction of IL-1 receptor-associated kinase-M in THP-1 cells by LPS derived from Porphyromonas gingivalis (2008)
  • Author(s): Domon H, Honda T, Oda T, Yoshie H, Yamazaki K
  • Journal Title: J Leukoc Biol 83 Pages: 672-679
  • Peer Reviewed
• [Presentation] ヒト歯肉上皮細胞のケモカイン産生におけるIRAK-M の関与 (2008)
  • Author(s): 高橋直紀,本田朋之,奥井隆文,土門久哲,吉江弘正,多部田康一,山崎和久
  • Organizer: 第51回秋季日本歯周病学会学術大会
  • Place of Presentation: 四日市市
  • Year and Date: 2008-10-19
• [Presentation] Differential induction of interleukin-1 receptor-associated kinase-M in THP-1 cells by lipopolysaccharide derived from Porphyromonas gingivalis (2007)
  • Author(s): Domon H, Honda T, Oda T, Yamazaki K
  • Organizer: 13th International congress of mucosal immunology
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2007-07-11