Development of safety and effective oral and nasal vaccines against P.Gingivalis infection

2008 Fiscal Year Final Research Report

• Project/Area Number: 19791624
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Nihon University
• Principal Investigator: HASHIZUME Tomomi Nihon University, 松戸歯学部, 助手 (50419785)
• Project Period (FY): 2007 – 2008
• Keywords: Porphyromonas gingivalis / 40k-OMP / 歯周病予防 / コレラ毒素

Research Abstract

歯周病原性細菌Porphromonas gingivalisの主要病原因子である外膜タンパク40k-OMPと、アジュバントである無毒化コレラ毒素Aサブユニットと大腸菌易熱性毒素Bサブユニットのキメラ分子(mCTA/LTB)をマウスに共投与すると長期間効果的な抗原特異的免疫応答の誘導保持、歯槽骨吸収の抑制を示した。従って40k-OMP+mCTA/LTB投与は歯周病予防ワクチンとして有効であることが示唆された。

Research Products

• [Journal Article] Nasal Vaccination with outer Membrane Protein of Porphyromonas gingivalis and Nontoxic Chimeric Enterotoxin Adjuvant Induces Both T Helper 1 and T Helper 2 Responses (2009)
  • Author(s): Fumiki Momoi, Tomomi Hashizume, et al
  • Journal Title: Int. J. Oral-Med. Sci 7 Pages: 145-153
  • Peer Reviewed
• [Journal Article] Nasal Vaccination with the 40-Kilodalton outer Membrane Protein of Porphyromonas gingivalis and a Nontoxic Chimeric Enterotoxin Adjuvant Induces Long-Term Protective Immunity with Reduced Levels of Immunoglobulin E Antibodies, (2008)
  • Author(s): Fumiki Momoi, Tomomi Hashizume, et al
  • Journal Title: Infect. Immun. 76 Pages: 2777-2784
  • Peer Reviewed
• [Presentation] Nasal Vaccination with the 40-Kda oute membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of IgE (2008)
  • Author(s): 桃井文藝,橋爪智美,その他
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] 無毒化キメラ分子アジュバントとP.gingivalis外膜タンパクの経鼻ワクチンによる免疫応答の誘導 (2008)
  • Author(s): 桃井文藝,橋爪智美,その他
  • Organizer: 第50回歯科基礎医学会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-25
• [Presentation] Nasal immunization with outer membrane protein of Porphyromonas gingivalis plus nontoxic chimeric enterotoxin adjuvant elicite protective immunity against P. gingivalis infection (2007)
  • Author(s): Fumiki Momoi, Tomomi Hashizume, et al
  • Organizer: 13th International Congress of Immunology
  • Place of Presentation: リオデジャネイロ
  • Year and Date: 2007-08-23
• [Presentation] A nontoxic chimeric enterotoxin adjuvant for oral immunity to outer membrane protein of Porphromonas gingivalis (2007)
  • Author(s): Fumiki Momoi, Tomomi Hashizume, et al
  • Organizer: 13th International Congress of Mucosal Immunology
  • Place of Presentation: 東京
  • Year and Date: 2007-07-11