2009 Fiscal Year Final Research Report
Consolidated research on periodontal regeneration using human umbilical cord derived cells
| Project/Area Number |
19791625
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
KANAZASHI Mikimoto Tsurumi University, 歯学部, 助教 (80339811)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 歯学 / 臍帯 / 再生医学 / 移植・再生医療 / 細胞・組織 |
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| Research Abstract |
We studied the possibility of tissue regeneration using human umbilical cord derived cells. Frow cytometry revealed the prospective evaluation that is most of the cells were CD44 positive, CD34 negative, wherese most cells were STRO-1 negative.
Following AA, β-GP and Dex treatment, cells failed to fuse and transdifferantiated along an osteogenic pathway expressing OC, BSP and COL I.These results show that human umbilical cord derived cells pluripotent stem cells capable of differentiation along osteogenic lineages.
Human umbilical cord derived cells may be have a possibility for the development of new tissue regeneration therapies.
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