Electret β-TCP particle composited chitosan tube for peripheral nerve regeneration

2008 Fiscal Year Final Research Report

• Project/Area Number: 19800011
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OU Gi Tokyo Medical and Dental University, 生体材料工学研究所, 研究機関研究員 (60451944)
• Project Period (FY): 2007 – 2008
• Keywords: 再生医工学材料

Research Abstract

電気分極β-TCP微粒子をキトサン繊維多孔体チューブの外層に固定し複合神経架橋用チューブを作製した。ラットの坐骨神経モデルを用いて神経移植材としての有効性を検討した。自家神経移植に相当する再生結果が得られた。

Research Products

• [Journal Article] Influences of Mechanical Properties and Permeability on Chitosan Nano/microfiber Mesh Tubes as a Scaffold for Nerve Regeneration (2008)
  • Author(s): Wang W., Itoh S., Matsuda A., Ichinose S., Shinomiya K., Hata Y., Tanaka J.
  • Journal Title: J.Biomed.Mater.Res.Part A Vol84 Pages: 557-566
• [Journal Article] Effects of Schwann cell alignment alongthe oriented electrospun chitosan nanofibers on nerve regeneration
  • Author(s): Wei Wang, Soichiro Itoh, Katsumi Konno, Takeshi Kikkawa, Shizuko Ichinose, Katsuyoshi Sakai, Tsuneo Ohkuma, Kazuhiko Watabe
  • Journal Title: J.Biomed.Mater.Res.Part A (In press)
• [Journal Article] Comparison of enhancement of bone ingrowth into hydroxyapatite ceramics with highly and lowly interconnected pores by Electrical Polarization
  • Author(s): Wei Wang, Soichiro Itoh, Yumi Tanaka, Akiko Nagai, Kimihiro Yamashita
  • Journal Title: Acta Biomaterialia (In press)
• [Presentation] 分極β-TCP粉体を用いた末梢神経再生 (2009)
  • Organizer: 日本セラミック協会2009年年会
  • Place of Presentation: 野田
  • Year and Date: 20090316-18
• [Presentation] Electret Bioceramics for bone Tissue Regeneration (2008)
  • Organizer: 日本バイオマテリアル学会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20081117-18
• [Presentation] (2008)
  • Organizer: Electret bioceramics for bone regeneration 2008CMCEE & LCS conference
  • Place of Presentation: Shanghai, China
  • Year and Date: 20081110-14
• [Presentation] Ingrowth into Hydroxyapatite with Interconnected Pores by Electrical Polarization (2008)
  • Author(s): Enhanced Bone
  • Organizer: 8th World Biomaterials Congress 2008
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 20080528-0601
• [Presentation] 国内バイオセラミックスの電気分極処理及び生体に及ぼす影響 (2008)
  • Organizer: 第7回日本再生医療学会
  • Place of Presentation: 名古屋
  • Year and Date: 20080313-14
• [Presentation] Osteoconductivity of Hydroxyapatite by Electrical Polarization Processing (2008)
  • Author(s): Enhanced
  • Organizer: The 9th Japan-Korea Congress of Plasticand Reconstructive Surgery
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 20080221-23