2008 Fiscal Year Final Research Report
Modulation of the redox status and immune function by ketone body in chicken.
| Project/Area Number |
19880036
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | National Agricultural Research Organization |
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Principal Investigator |
OHTSU Haruhiko National Agricultural Research Organization, 畜産草地研究所機能性飼料研究チーム, 研究員 (40455316)
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| Project Period (FY) |
2007 – 2008
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| Keywords | ケトン体 / ストレス / 免疫 / 応用動物 / 生理 |
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| Research Abstract |
Effects of ketone body, an intermediator of fatty acid β-oxidation in liver, on the redox status and immune function in chicken were investigated in vitro and in vi vo. High concentration of ketone body reduced the cell viability and increased the mRNA expression of cyclooxygenasell (COXII), an inflammatory factor, in chicken lymphocyte. Furthermore, plasma antioxidant activity was decreased, and the expression of spleen COXII mRNA was increased in chicken with ketosis, suggesting that ketone body increased oxidative stress and decreased immune function in chicken.
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