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2008 Fiscal Year Final Research Report

Molecular biological approaches to the interface between the host and parasite in the foci of periodontitis

Research Project

  • PDF
Project/Area Number 19890031
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionTohoku University

Principal Investigator

MAYANAGI Gen  Tohoku University, 病院, 医員 (10451600)

Project Period (FY) 2007 – 2008
Keywords歯学 / 免疫学 / 細菌学 / 遺伝学
Research Abstract

本研究により、健康な歯肉縁下プラークでは、通性嫌気性の歯面初期付着細菌が優勢で、歯周炎患者では、嫌気性菌が優勢であったことから、歯周炎の進行に伴って、嫌気性菌の増殖に適した環境へとシフトすることが示唆された。さらに、歯周ポケットが深くなると、骨吸収に関与しているとされるIL-6の検出量が増加傾向にあることが明らかになった。これらの結果を日常臨床にフィードバックし、歯周病診断に活かすことにより、国民の健康の確立に大きく寄与できるものと期待している。

  • Research Products

    (8 results)

All 2009 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results) Book (4 results)

  • [Journal Article] Probiotic effects of orally administered Lactobacillus salivarius WB21-containing tablets on periodontopathic bacteria : A double-blinded, placebo-controlled, randomized clinical trial2009

    • Author(s)
      Mayanagi G, Kimura M, Nakaya S, Hirata H, Sakamoto M, Benno Y and Shimauchi H
    • Journal Title

      Journal of Clinical Periodontology (in press)

    • Peer Reviewed
  • [Journal Article] Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21 : a randomized, double-blind, placebo-controlled study2008

    • Author(s)
      Shimauchi H, Mayanagi G, Nakaya S, Minamibuchi M, Ito Y, Yamaki K, Hirata H
    • Journal Title

      Journal of Clinical Periodontology 35(10)

      Pages: 897-905

    • Peer Reviewed
  • [Journal Article] Nested PCR for the sensitive detection of cariogenic bacteria2007

    • Author(s)
      Sato T, Matsuyama J, Mayanagi G, Abiko Y, Kato K and Takahashi N
    • Journal Title

      Cariology Today 3&4(1)

      Pages: 17-20

    • Peer Reviewed
  • [Presentation] 歯周病関連細菌に対するLactobacillus salivarius WB21株の影響2007

    • Author(s)
      中谷清吾、大山祐賀子、真柳弦、八巻恵子、伊藤康博、南渕麻衣子、平田晴久、島内英俊
    • Organizer
      第50回日本歯周病学会春季学術大会
    • Place of Presentation
      横須賀
    • Year and Date
      2007-05-18
  • [Book] Effects of orally administered Lactobacillus salivarius WB21 supplement on periodontal clinical parameters and microflora2007

    • Author(s)
      Mayanagi G, Nakaya S, Yamaki K, Ito Y, Minamibuchi M, Kimura M, Hirata H and Shimauchi H
    • Total Pages
      269-270
    • Publisher
      Interface Oral Health Science, Springer, Tokyo
  • [Book] Detection of periodontopathic bacteria in periodontal pockets by nested polymerase chain reaction2007

    • Author(s)
      Sato T, Abiko Y, Mayanagi G, Matsuyama J and Takahashi N
    • Total Pages
      267-268
    • Publisher
      Interface Oral Health Science, Springer, Tokyo
  • [Book] Microflora profiling of root canal utilizing real-time PCR and cloning-sequence analyses based on 16S rRNA genes-Differences between before and after root canal treatments-2007

    • Author(s)
      Ito Y, Sato T, Mayanagi G, Yamaki K, Shimauchi H and Takahashi N
    • Total Pages
      265-266
    • Publisher
      Interface Oral Health Science, Springer, Tokyo
  • [Book] Profiling of subgingival plaque biofilm microflora of healthy and periodontitis subjects by real-time PCR2007

    • Author(s)
      Abiko Y, Sato T, Mayanagi G and Takahashi N
    • Total Pages
      213-217
    • Publisher
      Interface Oral Health Science, Springer, Tokyo

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Published: 2010-06-10   Modified: 2016-04-21  

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