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2008 Fiscal Year Final Research Report

Development of a novel chamber applicable to various electrophysiological measurements

Research Project

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Project/Area Number 19890086
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionUniversity of Fukui

Principal Investigator

IWAMOTO Masayuki  University of Fukui, 医学部, 助教 (40452122)

Project Period (FY) 2007 – 2008
Keywordsイオンチャネル / 脂質平面膜 / パッチクランプ
Research Abstract

本研究ではイオンチャネル蛋白質の機能を調べるための新しい電気生理測定系の開発を目指した。従来、測定対象とするイオンチャネルの存在環境(人工脂質膜中または細胞膜中など)によって異なる測定系を用いる必要があったが、新たに開発した測定方法ではこの制約を無くす事ができた。従って、多種多様なイオンチャネルに対し共通のプラットフォーム上での機能評価、およびイオンチャネルを標的とした創薬研究への応用が期待される。

  • Research Products

    (8 results)

All 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] The water-ion coupling ratio for ion permeation through the KcsA potassium channel : Dependencies on concentration and species of permeating ions2009

    • Author(s)
      Iwamoto M, Shimizu H, Oiki S
    • Journal Title

      Biophys.J 96

      Pages: 179

  • [Journal Article] Flux coupling between ion and water in the K+ selective pore2008

    • Author(s)
      Iwamoto M, Shimizu H, Oiki S
    • Journal Title

      J.Physiol.Sci 58

      Pages: 77

  • [Journal Article] Kチャネルのイオン透過機構 : 新しい流動電位測定法により明らかになったイオン-水流束比2008

    • Author(s)
      老木成稔, 安藤博之, 久野みゆき, 清水啓史, 岩本真幸
    • Journal Title

      生物物理 48

      Pages: 246-252

    • Peer Reviewed
  • [Journal Article] Global twisting motion of singlemolecular KcsA potassium channelupon gating2008

    • Author(s)
      Shimizu H, Iwamoto M, Konno T, Nihei A, Sasaki YC, Oiki S
    • Journal Title

      Cell 132

      Pages: 67-78

    • Peer Reviewed
  • [Presentation] The water-ion coupling ratio for ion permeation through the KcsA potassium channel: Dependencies on concentration and species of permeating ions2009

    • Author(s)
      Iwamoto M, Shimizu H, Oiki S
    • Organizer
      Biophysical Society 53rd Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-03-01
  • [Presentation] Water-ion coupling ratios for ion permeation through KcsA channel2008

    • Author(s)
      Iwamoto M, Shimizu H, Oiki S
    • Organizer
      Biophysical Society 52nd Annual Meeting
    • Place of Presentation
      Long Beach, USA
    • Year and Date
      20080200
  • [Presentation] 流動電位測定によるKcsAカリウムチャネルのイオン透過機構の検討2008

    • Author(s)
      岩本真幸、清水啓史、老木成稔
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-05
  • [Presentation] Flux coupling between ion and water in the K+ selective pore2008

    • Author(s)
      Iwamoto M, Shimizu H, Oiki S
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-25

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Published: 2010-06-10   Modified: 2016-04-21  

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