2008 Fiscal Year Final Research Report
Role of SCGB3A2 in pulmonary fibrosis
| Project/Area Number |
19890175
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Yokohama City University |
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Principal Investigator |
KUROTANI Reiko Yokohama City University, 医学部, 特任助教 (00453043)
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| Project Period (FY) |
2007 – 2008
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| Research Abstract |
ブレオマイシン(BLM)誘導性肺線維症モデルを用いて、SCGB3A2が肺線維症を改善することを明らかにし、その作用機序の解明を試みた。マイクロアレイによる遺伝子発現プロファイリングによりSCGB3A2がプロコラーゲン遺伝子群の発現を抑制することを明らかにした。このとき、サイトカインシグナル遺伝子発現が亢進することも明らかになった。
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[Journal Article] Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight.2008
Author(s)
Okumura S, Tsunematsu T, Bai Y, Jiao Q, Ono S, Suzuki S, Kurotani R, Sato M, Minamisawa S, Umemura S, Ishikawa Y.
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Journal Title
J Appl Physiol 105(1)
Pages: 173-9
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[Journal Article] Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease2008
Author(s)
Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y.
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Journal Title
Inflamm Bowel Dis. 14(7)
Pages: 908-920
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[Journal Article] Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress2007
Author(s)
Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, Iwatsubo K, Ulucan C, Kawabe J, Ghosh K, Vatner SF, Ishikawa Y.
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Journal Title
Circulation 116(16)
Pages: 1776-1783
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