Acute stress reaction in cerebral limbic system and brainstem

2008 Fiscal Year Final Research Report

• Project/Area Number: 19890189
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Legal medicine
• Research Institution: Osaka City University
• Principal Investigator: QUAN Li Osaka City University, 大学院・医学研究科, 助教 (60453130)
• Project Period (FY): 2007 – 2009
• Keywords: ストレス反応 / 大脳辺縁系 / 脳幹 / 神経病理 / 神経化学

Research Abstract

法医鑑定では, 犯罪被害者の死因のみならず, 生存時間や受傷時の苦痛・身体的行動能力などについての医学的立証が求められることがある.ヒトの死の直前における神経伝達物質の中, 特にカテコラミンの測定を中心として, 致死的外傷(侵害刺激)が中枢神経系に及ぼす急性ストレス反応を生化学的に評価し, ヒト(法医剖検例)における脳組織, 脳脊髄液および血液内に残された痕跡を分子病理学, 分子生物学および神経化学・生理学的指標を用いて多元多角的に分析した.

Research Products

• [Journal Article] Analyses of cardiac blood cells and serum proteins with regard to cause of death in forensic autopsy cases (2009)
  • Author(s): Quan L, Ishikawa T, Michiue T, Li DR, Zhao D, Yoshida C, Chen JH, Komatsu A, Azuma Y, Sakoda S, Zhu BL, Maeda H.
  • Journal Title: Leg Med (Tokyo) (Epub ahead of print)
• [Journal Article] Postmortem serum levels of pulmonary surfactant-associated proteins A and D with regard to the cause of death in medicolegal autopsy (2009)
  • Author(s): Quan L, Zhu BL, Ishikawa T, Michiue T, Zhao D, Yoshida C, Chen JH, Wang Q, Komatsu A, Azuma Y, Maeda H.
  • Journal Title: Leg Med (Tokyo) (Epub ahead of print)
• [Journal Article] Immunohistochemistry of von Willebrand factor in the lungs with regard to the cause of death in forensic autopsy (2009)
  • Author(s): Quan L, Ishikawa T, Zhao D, Michiue T, Yoshida C, Chen JH, Wang Q, Zhu BL, Maeda H.
  • Journal Title: Leg Med (Tokyo) (Epub ahead of print)
• [Journal Article] Quantitative analysis of single-stranded DNA immunoreactivity as a marker of neuronal apoptosis in hippocampus with regard to the causes of death in medicolegal autopsy (2009)
  • Author(s): Michiue T, Quan L, Ishikawa T, Zhu BL, Maeda H.
  • Journal Title: Leg Med(Tokyo) (Epub ahead of print)
• [Journal Article] Evaluation of postmortem calcium and magnesium levels in the pericardial fluid with regard to the cause of death in medicolegal autopsy (2009)
  • Author(s): Li DR, Quan L, Zhu BL, Ishikawa T, Michiue T, Zhao D, Yoshida C, Chen JH, Wang Q, Komatsu A, Azuma Y, Maeda H.
  • Journal Title: Leg Med (Tokyo) (Epub ahead of print)
• [Journal Article] Postmortem mRNA quantification for investigation of infantile death : A comparison with adult cases (2009)
  • Author(s): Zhao D, Ishikawa T, Quan L, Michiue T, Yoshida C, Komatu A, Chen JH, Wang Q,Zhu BL, Maeda H.
  • Journal Title: Leg Med (Tokyo) (Epub ahead of print)
• [Journal Article] Postmortem quantitative mRNA analyses of death investigation in forensic pathology : An overview and prospects (2009)
  • Author(s): Zhao D, Ishikawa T, Quan L, Michiue T, Zhu BL, Maeda H.
  • Journal Title: Leg Med (Tokyo) [Epub ahead of print]
• [Journal Article] Evaluation of pulmonary GLUT1 and VEGF mRNA levels in relation to lung weight in medicolegal autopsy cases (2009)
  • Author(s): Zhao D, Ishikawa T, Quan L, Michiue T, Yoshida C, Komatu A, Chen JH, Wang Q, Zhu BL, Maeda H.
  • Journal Title: Leg Med [Epub ahead of print]
• [Journal Article] Immunohistochemical distribution of basic fibroblast growth factor (bFGF) in medicolegal autopsy (2009)
  • Author(s): Wang Q, Ishikawa T, Quan L, Zhao D, Li DR, Michiue T, Chen JH, Zhu BL, Maeda H.
  • Journal Title: Leg Med (Tokyo) [Epub ahead of print]
• [Journal Article] Significance of postmortem biochemistry in determining the cause of death (2009)
  • Author(s): Maeda H, Zhu BL, Ishikawa T, Quan L, Michiue T.
  • Journal Title: Leg Med [Epub ahead of print]
• [Journal Article] Analysis of postmortem biochemical findings with regard to the lung weight in drowning (2009)
  • Author(s): Maeda H, Zhu BL, Ishikawa T, Quan L, Michiue T, Bessho Y, Okazaki S, Kamikodai Y, Tsuda K, Komatsu A, Azuma Y.
  • Journal Title: Leg Med [Epub ahead of print]
• [Journal Article] Postmortem serum erythropoietin levels in establishing the cause of death and survival time at medicolegal autopsy (2008)
  • Author(s): Quan L, Zhu BL, Ishikawa T, Michiue T, Zhao D, Li DR, Ogawa M, Maeda H.
  • Journal Title: Int J Legal Med 122(6) Pages: 481-7
  • Peer Reviewed
• [Journal Article] Postmortem biochemistry and immunohistochemistry of adrenocorticotropic hormone with special regard to fatal hypothermia (2008)
  • Author(s): Ishikawa T, Quan L, Li DR, Zhao D, Michiue T, Hamel M, Maeda H.
  • Journal Title: Forensic Sci Int 179(2-3) Pages: 147-51
  • Peer Reviewed
• [Journal Article] Single-stranded DNA as an immunohistochemical marker of neuronal damage in human brain : an analysis of autopsy material with regard to the cause of death (2008)
  • Author(s): Michiue T, Ishikawa T, Quan L, Li DR, Zhao D, Komatsu A, Zhu BL, Maeda H.
  • Journal Title: Forensic Sci Int 178(2-3) Pages: 185-91
  • Peer Reviewed
• [Journal Article] Suicidal vehicle-assisted ligature strangulation resulting in complete decapitation : Anautopsy report and a review of the literature (2008)
  • Author(s): Zhao D, Ishikawa T, Quan L, Li DR, Michiue T, Maeda H.
  • Journal Title: Leg Med 10(6) Pages: 310-5
  • Peer Reviewed
• [Journal Article] Immunohistochemical distribution of single-stranded DNA in the brain in medico-legal autopsy cases of carbon monoxide intoxication (2008)
  • Author(s): Michiue T, Ishikawa T, Quan L, Li DR, Komatsu A, Zhao D, Chen JH, Yoshida C, Ogawa M, Maeda H.
  • Journal Title: Chudoku Kenkyu 21(1) Pages: 63-8
  • Peer Reviewed
• [Journal Article] Tissue-specific differences in mRNA quantification of glucose transporter 1 and vascular endothelial growth factor with special regard to death investigations of fatal injuries (2008)
  • Author(s): Zhao D, Ishikawa T, Quan L, Li DR, Michiue T, Yoshida C, Komatu A, Chen JH, Zhu BL, Maeda H.
  • Journal Title: Forensic Sci Int 177(2-3) Pages: 176-83
  • Peer Reviewed
• [Journal Article] Forensic pathological evaluation of injury severity and fatal outcome in traffic accidents : five illustrative autopsy cases of clinically unexpected death (2008)
  • Author(s): Michiue T, Ishikawa T, Quan L, Zhu BL, Maeda H.
  • Journal Title: Forensic Sci Med Pathol 4(3) Pages: 153-8
  • Peer Reviewed
• [Journal Article] 片側性血胸に合併した対側性外傷性気胸による急死の1剖検例 (2008)
  • Author(s): 権力, 道上知美, 趙東, 李冬日, 石川隆紀, 前田均
  • Journal Title: 法医病理 (14) Pages: 22-28
  • Peer Reviewed
• [Presentation] Postmortem catecholamine levels in pericardial and cerebrospinal fluids with regard to the cause of death in medicolegal autopsy (2008)
  • Author(s): Quan L, Zhu B-L, Ishikawa T, Michiue T, Zhao D, Yoshida C, Chen J-H, Wang Q, Maeda H.
  • Organizer: 7th International Symposium Advances in Legal Medicine, Sep, Jpn J Legal Med 2008
  • Place of Presentation: Osaka(62 :138)
  • Year and Date: 20080901-05
• [Presentation] Postmortem serum erythropoietin and C-reactive Protein levels as markers of survival time in injury deaths (2008)
  • Author(s): Quan L, Zhu B-L, Ishikawa T, Michiue T, Zhao D, Yoshida C, Chen J-H, Wang Q, Komatsu A, Azuma Y, Maeda H.
  • Organizer: 7th International Symposium Advances in Legal Medicine, Sep, Jpn J Legal Med 2008
  • Place of Presentation: Osaka(62 : 138-139)
  • Year and Date: 20080901-05