2009 Fiscal Year Final Research Report
Local anesthetic effect of lidocaine with dexmedetomidine
| Project/Area Number |
19890229
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
TSUTSUI Yukako (中野 友花子) The Nippon Dental University, 生命歯学部, 助教 (20434144)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 塩酸デクスメデトミジン / α_2受容体 / 塩酸リドカイン / 局所麻酔 / 活動電位 |
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| Research Abstract |
Recent reports have examined that α_2-adrenoceptor agonist enhanced the local anesthesia effect of lidocaine in peripheral nerve. Dexmedetomidine (DEX) is known that a selective α_2-adrenoceptor agonist. We therefore hypothesized that lidocaine with DEX enhance the local anesthesia effect without unacceptable cardiovascular side effect. We investigated to effect of DEX on peripheral nerve. In addition, we determine local anesthetic effect of DEX with lidocaine. And also, we identified the pharmacological relationship of lidocaine and DEX by isobologram analysis on the rat sciatic nerve.
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