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2008 Fiscal Year Final Research Report

The clarification of the regulatory mechanism of calcium dynamics during osteoclastogenesis

Research Project

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Project/Area Number 19890273
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

KURODA Yukiko  The Institute of Physical and Chemical Research, 発生神経生物研究チーム, 基礎科学特別研究員 (70455343)

Project Period (FY) 2007 – 2008
Keywordsシグナル伝達 / 発生・分化 / 破骨細胞 / カルシウムシグナル
Research Abstract

申請者はIP3R結合タンパク質の一つであるIRBITをノックダウンすると破骨細胞分化因子RANKLによって誘導されるカルシウムオシレーションの始まるタイミングが早まる傾向があることを見いだした。この結果より、IRBITが破骨細胞分化誘導時のカルシウム動態に深く関わっている分子であることが明らかとなった。そこで、破骨細胞分化時、および未分化時にそれぞれ特異的にIRBITに結合するタンパク質のスクリーニングを行い、現在はその中の候補タンパク質の一つであるE3ユビキチンリガーゼに注目し、研究を進めている。

  • Research Products

    (6 results)

All 2009 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (1 results)

  • [Journal Article] Inositol 1,4,5-triphosphate receptor- binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation2009

    • Author(s)
      Kiefer H, Mizutani A, Iemura S, Natsume T, Ando H, Kuroda Y, Mikoshiba K
    • Journal Title

      J. Biol. Chem. 17;284(16)

      Pages: 010694-705

    • Peer Reviewed
  • [Journal Article] 80K-H interacts with inositol 1,4,5- trisphosphate (IP3) receptors and regulates IP3-induced calcium release activity2009

    • Author(s)
      Kawaai K, Hisatsune C, Kuroda Y, Mizutani A, Tashiro T, Mikoshiba K
    • Journal Title

      J. Biol. Chem. 2;284(1)

      Pages: 372-80

    • Peer Reviewed
  • [Journal Article] Osteoblasts induce Ca^<2+> Oscillation- independent NFATc1 activation during Osteoclastogenesis2008

    • Author(s)
      Kuroda Y, Hisatsune C, Nakamura T, Matsuo K, Mikoshiba K
    • Journal Title

      Proc. Natl. Acad. Sci. USA 24;105(25)

      Pages: 8643-8

    • Peer Reviewed
  • [Journal Article] Phosphorylation of Homer3 by CaMKII regulates a coupling state of its target molecules in Purkinje Cells2008

    • Author(s)
      Mizutani A, Kuroda Y, Futatsugi A, Furuichi T, Mikoshiba K
    • Journal Title

      J. Neurosci. 14;28(20)

      Pages: 5369-82

    • Peer Reviewed
  • [Journal Article] Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor2007

    • Author(s)
      Hisatsune C, Yasumatsu K, Takahashi- Iwanaga H, Ogawa N, Kuroda Y, Yoshida R, Ninomiya Y, Mikoshiba K
    • Journal Title

      J. Biol. Chem. 21; 282(51)

      Pages: 37225-31

    • Peer Reviewed
  • [Presentation] Osteoblasts induce Ca^<2+> oscillation-independent NFATc1 activation during osteoclastogenesis2008

    • Author(s)
      Kuroda Yukiko
    • Organizer
      Advanced Bone and Joint Science (ABJS) International Collaboration Symposium
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2008-12-04

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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